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P18065

Insulin-like growth factor-binding protein 2 (P18065)

Uniprot ID P18065
Protein Name Insulin-like growth factor-binding protein 2
Gene Name IGFBP2
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b) 0.896
Function Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. .
GO - Molecular function
  • insulin-like growth factor I binding : IDA:UniProtKB
  • insulin-like growth factor II binding : ISS:UniProtKB
  • signaling receptor binding : TAS:ParkinsonsUK-UCL
GO - Biological process
  • aging : IEA:Ensembl
  • cellular protein metabolic process : TAS:Reactome
  • cellular response to hormone stimulus : IEA:Ensembl
  • female pregnancy : IEA:Ensembl
  • negative regulation of canonical Wnt signaling pathway : TAS:ParkinsonsUK-UCL
  • positive regulation of activated T cell proliferation : IDA:BHF-UCL
  • regulation of growth : IEA:UniProtKB-KW
  • regulation of insulin-like growth factor receptor signaling pathway : ISS:UniProtKB
  • response to drug : IEA:Ensembl
  • response to estradiol : IEA:Ensembl
  • response to estrogen : IEA:Ensembl
  • response to glucocorticoid : IEA:Ensembl
  • response to lithium ion : IEA:Ensembl
  • response to mechanical stimulus : IEA:Ensembl
  • response to nutrient : IEA:Ensembl
  • response to retinoic acid : IEA:Ensembl
  • signal transduction : IEA:Ensembl
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.