| Signal peptide(a) |
Y |
Secretome P(b) |
0.841 |
| Function |
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R. . |
| GO - Molecular function |
- fibronectin binding : IBA:GO_Central
- insulin-like growth factor binding : NAS:UniProtKB
- insulin-like growth factor I binding : IPI:BHF-UCL
- insulin-like growth factor II binding : IBA:GO_Central
- metal ion binding : NAS:UniProtKB
- protein tyrosine phosphatase activator activity : IDA:UniProtKB
|
| GO - Biological process |
- apoptotic process : IEA:UniProtKB-KW
- cellular protein metabolic process : TAS:Reactome
- negative regulation of cell population proliferation : IGI:MGI
- negative regulation of protein phosphorylation : IDA:MGI
- negative regulation of signal transduction : NAS:UniProtKB
- negative regulation of smooth muscle cell migration : IDA:BHF-UCL
- negative regulation of smooth muscle cell proliferation : IDA:BHF-UCL
- osteoblast differentiation : IEA:Ensembl
- positive regulation of apoptotic process : IMP:UniProtKB
- positive regulation of insulin-like growth factor receptor signaling pathway : IEA:Ensembl
- positive regulation of MAPK cascade : IEA:Ensembl
- positive regulation of myoblast differentiation : IDA:UniProtKB
- post-translational protein modification : TAS:Reactome
- protein phosphorylation : IDA:MGI
- regulation of apoptotic process : TAS:Reactome
- regulation of cell growth : IEA:Ensembl
- regulation of glucose metabolic process : IEA:Ensembl
- regulation of insulin-like growth factor receptor signaling pathway : IBA:GO_Central
- type B pancreatic cell proliferation : IEA:Ensembl
|