Galectin-3 (P17931)

Uniprot ID P17931
Protein Name Galectin-3
Gene Name LGALS3
Species Homo sapiens (Human)
Signal peptide(a) N Secretome P(b) 0.84
Function Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. Together with TRIM16, coordinates the recognition of membrane damage with mobilization of the core autophagy regulators ATG16L1 and BECN1 in response to damaged endomembranes. .
GO - Molecular function
  • carbohydrate binding : TAS:ProtInc
  • chemoattractant activity : IDA:BHF-UCL
  • IgE binding : IDA:BHF-UCL
  • laminin binding : IDA:BHF-UCL
  • oligosaccharide binding : IDA:UniProtKB
  • protein phosphatase binding : IPI:ARUK-UCL
  • protein phosphatase inhibitor activity : IC:ARUK-UCL
  • RNA binding : HDA:UniProtKB
GO - Biological process
  • antimicrobial humoral immune response mediated by antimicrobial peptide : IDA:UniProtKB
  • eosinophil chemotaxis : IDA:BHF-UCL
  • epithelial cell differentiation : IEP:UniProtKB
  • innate immune response : IEA:UniProtKB-KW
  • killing of cells of other organism : IDA:UniProtKB
  • macrophage chemotaxis : IDA:BHF-UCL
  • monocyte chemotaxis : IDA:BHF-UCL
  • mononuclear cell migration : IDA:BHF-UCL
  • mRNA processing : IEA:UniProtKB-KW
  • negative regulation of endocytosis : IDA:BHF-UCL
  • negative regulation of extrinsic apoptotic signaling pathway : IDA:BHF-UCL
  • negative regulation of immunological synapse formation : ISS:BHF-UCL
  • negative regulation of protein tyrosine phosphatase activity : IC:ARUK-UCL
  • negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell : ISS:BHF-UCL
  • negative regulation of T cell receptor signaling pathway : ISS:BHF-UCL
  • neutrophil chemotaxis : IDA:BHF-UCL
  • neutrophil degranulation : TAS:Reactome
  • positive chemotaxis : IDA:BHF-UCL
  • positive regulation of calcium ion import : IDA:BHF-UCL
  • positive regulation of mononuclear cell migration : IDA:BHF-UCL
  • positive regulation of protein homodimerization activity : IDA:ARUK-UCL
  • positive regulation of protein localization to plasma membrane : IDA:ARUK-UCL
  • regulation of extrinsic apoptotic signaling pathway via death domain receptors : IMP:BHF-UCL
  • regulation of myeloid cell differentiation : TAS:Reactome
  • regulation of T cell apoptotic process : IDA:BHF-UCL
  • regulation of T cell proliferation : IMP:BHF-UCL
  • RNA splicing : IEA:UniProtKB-KW
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.