Signal peptide(a) |
N |
Secretome P(b) |
0.746 |
Function |
Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways. Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion (By similarity). . |
GO - Molecular function |
- chromatin binding : ISS:UniProtKB
- damaged DNA binding : ISS:UniProtKB
- dinucleotide insertion or deletion binding : ISO:MGI
- DNA polymerase binding : ISO:MGI
- DNA polymerase processivity factor activity : IBA:GO_Central
- enzyme binding : IPI:BHF-UCL
- estrogen receptor binding : ISO:MGI
- histone acetyltransferase binding : ISO:MGI
- identical protein binding : ISO:MGI
- MutLalpha complex binding : ISO:MGI
- purine-specific mismatch base pair DNA N-glycosylase activity : ISO:MGI
- receptor tyrosine kinase binding : ISO:MGI
|
GO - Biological process |
- base-excision repair, gap-filling : IDA:MGI
- cellular response to UV : ISS:UniProtKB
- cellular response to xenobiotic stimulus : IDA:MGI
- leading strand elongation : IBA:GO_Central
- mismatch repair : ISO:MGI
- mitotic telomere maintenance via semi-conservative replication : IGI:BHF-UCL
- negative regulation of transcription by RNA polymerase II : IDA:MGI
- positive regulation of deoxyribonuclease activity : ISS:UniProtKB
- positive regulation of DNA repair : ISS:UniProtKB
- positive regulation of DNA replication : ISS:UniProtKB
- replication fork processing : IGI:BHF-UCL
- response to lipid : ISO:MGI
- translesion synthesis : ISS:UniProtKB
|