Alpha-enolase (P17182)

Uniprot ID P17182
Protein Name Alpha-enolase
Gene Name Eno1
Species Mus musculus (Mouse)
Signal peptide(a) N Secretome P(b) 0.636
Function Multifunctional enzyme that, as well as its role in glycolysis, plays a part in various processes such as growth control, hypoxia tolerance and allergic responses (By similarity). May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production (By similarity). .
GO - Molecular function
  • cadherin binding : ISO:MGI
  • enzyme binding : ISO:MGI
  • GTPase binding : ISO:MGI
  • heat shock protein binding : ISO:MGI
  • magnesium ion binding : IEA:InterPro
  • phosphopyruvate hydratase activity : IDA:MGI
  • protein heterodimerization activity : IPI:MGI
  • protein homodimerization activity : ISO:MGI
  • RNA binding : IDA:MGI
  • RNA polymerase II regulatory region sequence-specific DNA binding : ISO:MGI
  • transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding : ISO:MGI
  • transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding : ISO:MGI
GO - Biological process
  • glycolytic process : IDA:MGI
  • in utero embryonic development : IMP:MGI
  • positive regulation of binding : IMP:MGI
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.