| Signal peptide(a) |
N |
Secretome P(b) |
0.6 |
| Function |
Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain. . |
| GO - Molecular function |
- carboxylic acid binding : IEA:Ensembl
- L-aspartate : IDA:UniProtKB
- L-cysteine : ISS:UniProtKB
- phosphatidylserine decarboxylase activity : IEA:Ensembl
- pyridoxal phosphate binding : IEA:InterPro
|
| GO - Biological process |
- 2-oxoglutarate metabolic process : ISS:UniProtKB
- aspartate biosynthetic process : IBA:GO_Central
- aspartate catabolic process : IDA:UniProtKB
- aspartate metabolic process : ISS:UniProtKB
- cellular amino acid biosynthetic process : TAS:Reactome
- cellular response to insulin stimulus : IEP:UniProtKB
- cellular response to mechanical stimulus : IEA:Ensembl
- fatty acid homeostasis : IEA:Ensembl
- gluconeogenesis : TAS:Reactome
- glutamate catabolic process to 2-oxoglutarate : IEA:Ensembl
- glutamate catabolic process to aspartate : IEA:Ensembl
- glutamate metabolic process : ISS:UniProtKB
- glycerol biosynthetic process : ISS:UniProtKB
- negative regulation of collagen biosynthetic process : IEA:Ensembl
- negative regulation of cytosolic calcium ion concentration : IEA:Ensembl
- negative regulation of mitochondrial depolarization : IEA:Ensembl
- Notch signaling pathway : IEA:Ensembl
- oxaloacetate metabolic process : IEA:Ensembl
- positive regulation of transforming growth factor beta receptor signaling pathway : IEA:Ensembl
- response to cadmium ion : IEA:Ensembl
- response to carbohydrate : IEA:Ensembl
- response to glucocorticoid : IEP:UniProtKB
- response to immobilization stress : IEA:Ensembl
- response to transition metal nanoparticle : IEA:Ensembl
- transdifferentiation : IEA:Ensembl
|