Home Proteins Experiments Diseases Interactions Tutorial
Home
/
Proteins
/
P17108

Interleukin-2 (P17108)

Uniprot ID P17108
Protein Name Interleukin-2
Gene Name Il2
Species Rattus norvegicus (Rat)
Basic Information Experiments (3) Disease (16) Interactions
Signal peptide(a) Y Secretome P(b)
Function Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.
GO - Molecular function
  • carbohydrate binding : IDA:RGD
  • cytokine activity : IDA:RGD
  • glycosphingolipid binding : IDA:RGD
  • growth factor activity : IEA:UniProtKB-KW
  • interleukin-2 receptor binding : IMP:RGD
  • kappa-type opioid receptor binding : IMP:RGD
GO - Biological process
  • adaptive immune response : IEA:UniProtKB-KW
  • extrinsic apoptotic signaling pathway in absence of ligand : ISO:RGD
  • G protein-coupled receptor signaling pathway : IMP:RGD
  • leukocyte activation involved in immune response : ISO:RGD
  • negative regulation of B cell apoptotic process : ISO:RGD
  • negative regulation of heart contraction : IDA:RGD
  • negative regulation of inflammatory response : ISO:RGD
  • negative regulation of lymphocyte proliferation : ISO:RGD
  • negative regulation of protein phosphorylation : IDA:RGD
  • negative regulation of T-helper 17 cell differentiation : ISO:RGD
  • positive regulation of activated T cell proliferation : ISO:RGD
  • positive regulation of B cell proliferation : ISO:RGD
  • positive regulation of cytosolic calcium ion concentration : IDA:RGD
  • positive regulation of dendritic spine development : IDA:RGD
  • positive regulation of immunoglobulin secretion : ISO:RGD
  • positive regulation of interferon-gamma production : ISO:RGD
  • positive regulation of interleukin-17 production : ISO:RGD
  • positive regulation of isotype switching to IgG isotypes : ISO:RGD
  • positive regulation of protein phosphorylation : IDA:RGD
  • positive regulation of regulatory T cell differentiation : IDA:RGD
  • positive regulation of T cell differentiation : IDA:RGD
  • positive regulation of T cell proliferation : IDA:RGD
  • positive regulation of transcription by RNA polymerase II : ISO:RGD
  • positive regulation of tyrosine phosphorylation of STAT protein : ISO:RGD
  • protein kinase C-activating G protein-coupled receptor signaling pathway : IMP:RGD
  • regulation of T cell homeostatic proliferation : ISO:RGD
  • response to ethanol : IDA:RGD
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.