SPARC (P16975)

Uniprot ID P16975
Protein Name SPARC
Gene Name Sparc
Species Rattus norvegicus (Rat)
Signal peptide(a) Y Secretome P(b) 0.914
Function Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.
GO - Molecular function
  • calcium ion binding : IDA:RGD
  • collagen binding : ISO:RGD
  • extracellular matrix binding : ISO:RGD
GO - Biological process
  • bone development : ISO:RGD
  • cellular response to growth factor stimulus : ISO:RGD
  • heart development : IEP:RGD
  • inner ear development : IEP:RGD
  • lung development : IMP:RGD
  • negative regulation of angiogenesis : ISO:RGD
  • negative regulation of endothelial cell proliferation : ISO:RGD
  • ossification : IEP:RGD
  • pigmentation : ISO:RGD
  • positive regulation of endothelial cell migration : ISO:RGD
  • regulation of cell morphogenesis : ISO:RGD
  • regulation of cell population proliferation : ISO:RGD
  • regulation of synapse organization : IDA:SynGO
  • response to cadmium ion : IEP:RGD
  • response to calcium ion : IEP:RGD
  • response to cAMP : IEP:RGD
  • response to cytokine : IEP:RGD
  • response to ethanol : IEP:RGD
  • response to glucocorticoid : IEP:RGD
  • response to gravity : IEP:RGD
  • response to L-ascorbic acid : IEP:RGD
  • response to lead ion : IEP:RGD
  • response to lipopolysaccharide : IEP:RGD
  • response to peptide hormone : IEP:RGD
  • wound healing : IEP:RGD
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.