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P16885

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (P16885)

Uniprot ID P16885
Protein Name 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
Gene Name PLCG2
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.0
Function The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling.
GO - Molecular function
  • phosphatidylinositol phospholipase C activity : IDA:UniProtKB
  • phospholipase C activity : TAS:Reactome
  • phosphotyrosine residue binding : IPI:CAFA
GO - Biological process
  • activation of store-operated calcium channel activity : IEA:Ensembl
  • B cell differentiation : ISS:UniProtKB
  • B cell receptor signaling pathway : ISS:UniProtKB
  • calcium-mediated signaling : NAS:UniProtKB
  • Fc-epsilon receptor signaling pathway : TAS:Reactome
  • Fc-gamma receptor signaling pathway involved in phagocytosis : TAS:Reactome
  • follicular B cell differentiation : IEA:Ensembl
  • inositol phosphate metabolic process : TAS:Reactome
  • inositol trisphosphate biosynthetic process : IEA:Ensembl
  • negative regulation of programmed cell death : IEA:Ensembl
  • phosphatidylinositol biosynthetic process : IDA:UniProtKB
  • phospholipid catabolic process : IEA:InterPro
  • platelet activation : TAS:Reactome
  • positive regulation of receptor internalization : IEA:Ensembl
  • positive regulation of type I interferon production : IEA:Ensembl
  • regulation of gene expression : IEA:Ensembl
  • release of sequestered calcium ion into cytosol : IDA:UniProtKB
  • response to lipopolysaccharide : IEA:Ensembl
  • stimulatory C-type lectin receptor signaling pathway : TAS:Reactome
  • T cell receptor signaling pathway : ISS:UniProtKB
  • Wnt signaling pathway : TAS:UniProtKB
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.