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P16870

Carboxypeptidase E (P16870)

Uniprot ID P16870
Protein Name Carboxypeptidase E
Gene Name CPE
Species Homo sapiens (Human)
Basic Information Experiments (2) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b) 0.448
Function Removes residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone processing. Processes proinsulin.
GO - Molecular function
  • carboxypeptidase activity : TAS:ProtInc
  • cell adhesion molecule binding : IPI:BHF-UCL
  • metallocarboxypeptidase activity : IBA:GO_Central
  • neurexin family protein binding : IPI:BHF-UCL
  • serine-type carboxypeptidase activity : IBA:GO_Central
  • zinc ion binding : IEA:InterPro
GO - Biological process
  • cardiac left ventricle morphogenesis : IMP:BHF-UCL
  • cellular protein modification process : NAS:UniProtKB
  • insulin processing : IBA:GO_Central
  • neuropeptide signaling pathway : NAS:UniProtKB
  • protein localization to membrane : IDA:BHF-UCL
  • Wnt signaling pathway : IDA:CACAO
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.