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P16638

ATP-citrate synthase (P16638)

Uniprot ID P16638
Protein Name ATP-citrate synthase
Gene Name Acly
Species Rattus norvegicus (Rat)
Basic Information Experiments (1) Disease (2) Interactions
Signal peptide(a) N Secretome P(b)
Function Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis. .
GO - Molecular function
  • ATP binding : IEA:UniProtKB-KW
  • ATP citrate synthase activity : IDA:UniProtKB
  • cofactor binding : IEA:InterPro
  • metal ion binding : IEA:UniProtKB-KW
GO - Biological process
  • acetyl-CoA biosynthetic process : ISO:RGD
  • acetyl-CoA metabolic process : IDA:RGD
  • citrate metabolic process : IDA:RGD
  • fatty acid biosynthetic process : IDA:RGD
  • lipid biosynthetic process : ISS:UniProtKB
  • lipid metabolic process : IEP:RGD
  • oxaloacetate metabolic process : ISO:RGD
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.