| Signal peptide(a) |
Y |
Secretome P(b) |
|
| Function |
Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin (PubMed:16432278). Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture (By similarity). . |
| GO - Molecular function |
- collagen binding : ISS:UniProtKB
- copper ion binding : IMP:RGD
- protein-lysine 6-oxidase activity : IDA:RGD
|
| GO - Biological process |
- aorta development : ISO:RGD
- ascending aorta development : ISO:RGD
- blood vessel development : ISO:RGD
- blood vessel morphogenesis : ISS:UniProtKB
- bone mineralization : ISO:RGD
- cell chemotaxis : IMP:MGI
- cellular response to chemokine : ISO:RGD
- cellular response to organic substance : ISO:RGD
- collagen fibril organization : IDA:RGD
- connective tissue development : ISO:RGD
- descending aorta development : ISO:RGD
- DNA biosynthetic process : ISO:RGD
- elastic fiber assembly : IMP:RGD
- heart development : ISO:RGD
- lung development : ISO:RGD
- muscle cell cellular homeostasis : ISO:RGD
- muscle fiber development : ISO:RGD
- osteoblast differentiation : ISO:RGD
- peptidyl-lysine oxidation : ISS:UniProtKB
- platelet-derived growth factor receptor-beta signaling pathway : IMP:MGI
- protein kinase B signaling : ISO:RGD
- protein oxidation : IMP:MGI
- regulation of apoptotic process : ISO:RGD
- regulation of bone development : ISO:RGD
- regulation of gene expression : ISO:RGD
- regulation of megakaryocyte differentiation : ISO:RGD
- regulation of platelet-derived growth factor receptor-beta signaling pathway : ISO:RGD
- regulation of protein phosphorylation : ISO:RGD
- regulation of receptor binding : IMP:MGI
- regulation of striated muscle tissue development : ISO:RGD
- regulation of transforming growth factor beta receptor signaling pathway : ISO:RGD
- response to drug : IEP:RGD
- response to hormone : IDA:RGD
- response to steroid hormone : IDA:RGD
- wound healing : IMP:RGD
|