Vascular endothelial growth factor A (P16612)

Uniprot ID	P16612
Protein Name	Vascular endothelial growth factor A
Gene Name	Vegfa
Species	Rattus norvegicus (Rat)

Signal peptide^(a)	N	Secretome P^(b)	0.0
Function	Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. May play a role in increasing vascular permeability during lactation, when increased transport of molecules from the blood is required for efficient milk protein synthesis. Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity). .
GO - Molecular function	chemoattractant activity : IMP:RGD cytokine activity : ISO:RGD extracellular matrix binding : ISO:RGD fibronectin binding : ISO:RGD growth factor activity : IDA:RGD growth factor binding : IPI:RGD heparin binding : ISO:RGD identical protein binding : IPI:RGD neuropilin binding : ISO:RGD platelet-derived growth factor receptor binding : ISO:RGD protein heterodimerization activity : ISO:RGD receptor ligand activity : ISO:RGD signaling receptor binding : ISO:RGD vascular endothelial growth factor receptor 1 binding : ISO:RGD vascular endothelial growth factor receptor 2 binding : IMP:RGD vascular endothelial growth factor receptor binding : ISO:RGD
GO - Biological process	activation of protein kinase activity : ISO:RGD aging : IEP:RGD angiogenesis : IMP:RGD angiogenesis involved in coronary vascular morphogenesis : IMP:RGD artery morphogenesis : ISO:RGD basophil chemotaxis : ISO:RGD blood vessel development : ISO:RGD blood vessel endothelial cell proliferation involved in sprouting angiogenesis : ISO:RGD blood vessel morphogenesis : ISO:RGD blood vessel remodeling : IMP:RGD bone trabecula formation : ISO:RGD bone trabecula morphogenesis : ISO:RGD branching involved in blood vessel morphogenesis : ISO:RGD branching morphogenesis of an epithelial tube : ISO:RGD camera-type eye morphogenesis : ISO:RGD cardiac muscle fiber development : ISO:RGD cardiac vascular smooth muscle cell development : ISO:RGD cell chemotaxis : IMP:RGD cell maturation : ISO:RGD cell migration : ISO:RGD cell migration involved in sprouting angiogenesis : ISO:RGD cell population proliferation : ISO:RGD cellular response to dexamethasone stimulus : IEP:RGD cellular response to drug : IEP:RGD cellular response to fibroblast growth factor stimulus : IEP:RGD cellular response to hypoxia : ISO:RGD cellular response to vascular endothelial growth factor stimulus : ISO:RGD cellular stress response to acid chemical : ISO:RGD commissural neuron axon guidance : ISO:RGD coronary artery morphogenesis : ISO:RGD coronary vein morphogenesis : ISO:RGD dopaminergic neuron differentiation : ISO:RGD endothelial cell chemotaxis : ISO:RGD endothelial cell migration : ISO:RGD epithelial cell differentiation : ISO:RGD eye photoreceptor cell development : ISO:RGD female pregnancy : IEP:RGD heart morphogenesis : ISO:RGD homeostasis of number of cells within a tissue : ISO:RGD hyaluronan metabolic process : IEP:RGD in utero embryonic development : ISO:RGD induction of positive chemotaxis : ISO:RGD kidney development : ISO:RGD lactation : ISO:RGD lung alveolus development : IMP:RGD lung development : ISO:RGD lung vasculature development : ISO:RGD lymph vessel morphogenesis : ISO:RGD lymphangiogenesis : ISO:RGD macrophage differentiation : ISO:RGD mammary gland alveolus development : ISO:RGD mesoderm development : ISO:RGD monocyte differentiation : ISO:RGD motor neuron migration : ISS:UniProtKB mRNA stabilization : IDA:RGD negative regulation of adherens junction organization : ISO:RGD negative regulation of apoptotic process : ISO:RGD negative regulation of bone resorption : IMP:RGD negative regulation of cell-cell adhesion : ISO:RGD negative regulation of cell-cell adhesion mediated by cadherin : ISO:RGD negative regulation of cysteine-type endopeptidase activity involved in apoptotic process : ISO:RGD negative regulation of epithelial to mesenchymal transition : ISO:RGD negative regulation of establishment of endothelial barrier : ISO:RGD negative regulation of extrinsic apoptotic signaling pathway : ISO:RGD negative regulation of fat cell differentiation : ISO:RGD negative regulation of gene expression : ISO:RGD negative regulation of neuron apoptotic process : ISO:RGD negative regulation of neuron death : IMP:RGD negative regulation of programmed cell death : IMP:RGD negative regulation of transcription by RNA polymerase II : ISO:RGD nervous system development : IDA:RGD neuron development : ISO:RGD outflow tract morphogenesis : ISO:RGD ovarian follicle development : ISO:RGD positive chemotaxis : ISO:RGD positive regulation of angiogenesis : IDA:RGD positive regulation of axon extension involved in axon guidance : ISO:RGD positive regulation of blood vessel endothelial cell migration : ISO:RGD positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis : ISO:RGD positive regulation of branching involved in ureteric bud morphogenesis : ISO:RGD positive regulation of cell adhesion : ISO:RGD positive regulation of cell division : IEA:UniProtKB-KW positive regulation of cell migration : ISO:RGD positive regulation of cell migration involved in sprouting angiogenesis : ISO:RGD positive regulation of cell population proliferation : IMP:RGD positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway : ISO:RGD positive regulation of cellular component movement : ISO:RGD positive regulation of cold-induced thermogenesis : ISS:YuBioLab positive regulation of CREB transcription factor activity : ISO:RGD positive regulation of DNA biosynthetic process : ISO:RGD positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway : ISO:RGD positive regulation of endothelial cell migration : ISS:UniProtKB positive regulation of endothelial cell proliferation : ISS:UniProtKB positive regulation of epithelial cell proliferation : ISO:RGD positive regulation of ERK1 and ERK2 cascade : ISO:RGD positive regulation of focal adhesion assembly : ISS:UniProtKB positive regulation of gene expression : ISO:RGD positive regulation of histone deacetylase activity : ISO:RGD positive regulation of lymphangiogenesis : ISO:RGD positive regulation of MAP kinase activity : ISO:RGD positive regulation of mast cell chemotaxis : ISO:RGD positive regulation of mesenchymal cell proliferation : ISO:RGD positive regulation of neuroblast proliferation : ISO:RGD positive regulation of osteoblast differentiation : ISO:RGD positive regulation of p38MAPK cascade : ISO:RGD positive regulation of peptidyl-serine phosphorylation : ISO:RGD positive regulation of peptidyl-tyrosine autophosphorylation : ISO:RGD positive regulation of peptidyl-tyrosine phosphorylation : ISS:UniProtKB positive regulation of phosphorylation : ISO:RGD positive regulation of positive chemotaxis : ISO:RGD positive regulation of protein autophosphorylation : ISO:RGD positive regulation of protein kinase B signaling : ISO:RGD positive regulation of protein kinase C signaling : ISO:RGD positive regulation of protein kinase D signaling : ISO:RGD positive regulation of protein localization to early endosome : ISO:RGD positive regulation of protein phosphorylation : ISS:UniProtKB positive regulation of protein-containing complex assembly : ISS:UniProtKB positive regulation of receptor internalization : ISO:RGD positive regulation of retinal ganglion cell axon guidance : ISO:RGD positive regulation of signal transduction : IDA:RGD positive regulation of smooth muscle cell proliferation : IMP:RGD positive regulation of sprouting angiogenesis : ISO:RGD positive regulation of transcription by RNA polymerase II : IDA:RGD positive regulation of transcription from RNA polymerase II promoter in response to hypoxia : ISO:RGD positive regulation of vascular endothelial growth factor receptor signaling pathway : ISO:RGD positive regulation of vascular permeability : IMP:RGD post-embryonic camera-type eye development : ISO:RGD primitive erythrocyte differentiation : ISO:RGD regulation of cell shape : ISO:RGD regulation of endothelial cell differentiation : ISO:RGD regulation of growth : ISO:RGD regulation of hematopoietic progenitor cell differentiation : ISO:RGD regulation of nitric oxide mediated signal transduction : ISO:RGD regulation of retinal ganglion cell axon guidance : ISO:RGD regulation of transcription by RNA polymerase II : ISO:RGD response to cold : IEP:RGD response to dexamethasone : IEP:RGD response to estradiol : IEP:RGD response to folic acid : IEP:RGD response to hypoxia : IDA:RGD response to oxygen levels : IEP:RGD response to progesterone : IEP:RGD response to vitamin A : IEP:RGD retina blood vessel maintenance : ISO:RGD sprouting angiogenesis : ISO:RGD surfactant homeostasis : ISO:RGD T-helper 1 type immune response : IDA:RGD tube formation : ISS:UniProtKB vascular endothelial growth factor receptor signaling pathway : IMP:RGD vascular endothelial growth factor signaling pathway : ISO:RGD vasculature development : ISO:RGD VEGF-activated neuropilin signaling pathway : ISO:RGD wound healing : IEP:RGD

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^{(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.}
^{(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.}