| Signal peptide(a) |
N |
Secretome P(b) |
0.927 |
| Function |
Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance (By similarity). .The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells. {ECO:0000250|UniProtKB:P01375}. |
| GO - Molecular function |
- cytokine activity : TAS:RGD
- RNA polymerase II regulatory region sequence-specific DNA binding : IPI:ARUK-UCL
- tumor necrosis factor receptor binding : IDA:RGD
|
| GO - Biological process |
- acute inflammatory response : IEP:RGD
- apoptotic process : IDA:RGD
- calcium-mediated signaling : IDA:RGD
- cell activation : IDA:RGD
- circadian rhythm : IEP:RGD
- detection of mechanical stimulus involved in sensory perception of pain : IMP:RGD
- immune response : IEA:InterPro
- inflammatory response : TAS:RGD
- necroptotic signaling pathway : ISS:UniProtKB
- negative regulation of cell proliferation : IDA:RGD
- negative regulation of glucose import : IDA:RGD
- negative regulation of L-glutamate import across plasma membrane : IDA:RGD
- negative regulation of myelination : IMP:RGD
- positive regulation of action potential : IDA:RGD
- positive regulation of apoptotic process : IMP:RGD
- positive regulation of chemokine secretion : IDA:ARUK-UCL
- positive regulation of fractalkine biosynthetic process : IDA:ARUK-UCL
- positive regulation of gene expression : IDA:UniProtKB
- positive regulation of I-kappaB kinase/NF-kappaB signaling : IDA:ARUK-UCL
- positive regulation of inflammatory response : IMP:RGD
- positive regulation of interleukin-18 production : IMP:RGD
- positive regulation of mitotic nuclear division : IMP:RGD
- positive regulation of neuron apoptotic process : IMP:RGD
- positive regulation of NF-kappaB transcription factor activity : ISS:UniProtKB
- positive regulation of phosphatidylinositol 3-kinase signaling : IMP:ARUK-UCL
- positive regulation of protein kinase B signaling : IMP:ARUK-UCL
- positive regulation of protein localization to plasma membrane : IMP:ARUK-UCL
- positive regulation of protein transport : IDA:RGD
- positive regulation of synaptic transmission : IMP:RGD
- positive regulation of transcription by RNA polymerase II : IDA:ARUK-UCL
- regulation of transcription by RNA polymerase II : IDA:ARUK-UCL
- response to activity : IEP:RGD
- response to drug : IEP:RGD
- response to gold nanoparticle : IEP:RGD
- response to hypoxia : IEP:RGD
- response to lipopolysaccharide : IMP:UniProtKB
- response to mechanical stimulus : IEP:RGD
- response to radiation : IEP:RGD
- signal transduction : IDA:RGD
- skeletal muscle contraction : IEP:RGD
- toll-like receptor 3 signaling pathway : IMP:UniProtKB
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