Interleukin-1 alpha (P16598)

Uniprot ID	P16598
Protein Name	Interleukin-1 alpha
Gene Name	Il1a
Species	Rattus norvegicus (Rat)

Signal peptide^(a)	N	Secretome P^(b)
Function	Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.
GO - Molecular function	copper ion binding : ISS:UniProtKB cytokine activity : ISO:RGD interleukin-1 receptor binding : ISO:RGD
GO - Biological process	acute inflammatory response : IEP:RGD cellular response to heat : ISS:UniProtKB cellular response to lipopolysaccharide : IBA:GO_Central connective tissue replacement involved in inflammatory response wound healing : ISO:RGD cytokine-mediated signaling pathway : ISO:RGD ectopic germ cell programmed cell death : ISO:RGD extrinsic apoptotic signaling pathway in absence of ligand : ISO:RGD fever generation : IEA:UniProtKB-KW heart development : IEP:RGD inflammatory response : ISO:RGD inflammatory response to antigenic stimulus : IBA:GO_Central interleukin-1-mediated signaling pathway : ISO:RGD keratinization : IDA:RGD negative regulation of cell population proliferation : ISO:RGD negative regulation of establishment of Sertoli cell barrier : IDA:RGD positive regulation of angiogenesis : ISO:RGD positive regulation of cell division : IEA:UniProtKB-KW positive regulation of cytokine secretion : ISO:RGD positive regulation of ERK1 and ERK2 cascade : IDA:RGD positive regulation of gene expression : ISO:RGD positive regulation of I-kappaB kinase/NF-kappaB signaling : IDA:RGD positive regulation of interleukin-2 biosynthetic process : ISO:RGD positive regulation of interleukin-2 secretion : IMP:ARUK-UCL positive regulation of interleukin-6 production : IMP:RGD positive regulation of interleukin-6 secretion : IMP:ARUK-UCL positive regulation of JNK cascade : IDA:RGD positive regulation of mitotic nuclear division : ISO:RGD positive regulation of monocyte chemotactic protein-1 production : ISO:RGD positive regulation of neutrophil extravasation : ISO:RGD positive regulation of neutrophil migration : IMP:RGD positive regulation of prostaglandin secretion : IDA:RGD positive regulation of protein secretion : ISO:RGD positive regulation of steroid biosynthetic process : IDA:RGD positive regulation of stress-activated MAPK cascade : IDA:RGD positive regulation of transcription by RNA polymerase II : ISO:RGD positive regulation of tumor necrosis factor secretion : IMP:ARUK-UCL positive regulation of vascular endothelial growth factor production : ISO:RGD regulation of actin cytoskeleton organization : IDA:RGD regulation of sensory perception of pain : IDA:RGD response to copper ion : ISS:UniProtKB response to gamma radiation : IEP:RGD response to heat : IEP:RGD response to hypoxia : IEP:RGD response to L-ascorbic acid : IEP:RGD response to lipopolysaccharide : IEP:RGD response to organic cyclic compound : IEP:RGD response to organic substance : IEP:RGD response to organonitrogen compound : IEP:RGD response to ozone : IEP:RGD spermatogenesis : IEP:RGD wound healing : IEP:RGD

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^{(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.}
^{(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.}