CD44 antigen (P16070)

Uniprot ID	P16070
Protein Name	CD44 antigen
Gene Name	CD44
Species	Homo sapiens (Human)

Signal peptide^(a)	N	Secretome P^(b)	0.185
Function	Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment (PubMed:16541107, PubMed:19703720, PubMed:22726066). Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hematopoiesis, inflammation and response to bacterial infection (PubMed:7528188). Engages, through its ectodomain, extracellular matrix components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its cytoplasmic domain, protein complexes containing receptor kinases and membrane proteases (PubMed:18757307, PubMed:23589287). Such effectors include PKN2, the RhoGTPases RAC1 and RHOA, Rho-kinases and phospholipase C that coordinate signaling pathways promoting calcium mobilization and actin-mediated cytoskeleton reorganization essential for cell migration and adhesion (PubMed:15123640). .
GO - Molecular function	collagen binding : NAS:UniProtKB hyaluronic acid binding : IDA:UniProtKB transmembrane signaling receptor activity : IBA:GO_Central
GO - Biological process	cartilage development : IEP:UniProtKB cell adhesion : IDA:UniProtKB cell migration : IDA:UniProtKB cell-cell adhesion : NAS:UniProtKB cell-matrix adhesion : NAS:UniProtKB cellular response to fibroblast growth factor stimulus : IDA:UniProtKB extracellular matrix disassembly : TAS:Reactome extracellular matrix organization : TAS:Reactome hyaluronan catabolic process : IDA:UniProtKB inflammatory response : IBA:GO_Central interferon-gamma-mediated signaling pathway : TAS:Reactome leukocyte migration : TAS:Reactome monocyte aggregation : IMP:UniProtKB negative regulation of apoptotic process : IMP:UniProtKB negative regulation of cysteine-type endopeptidase activity involved in apoptotic process : IMP:UniProtKB negative regulation of DNA damage response, signal transduction by p53 class mediator : IDA:BHF-UCL negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator : IDA:BHF-UCL neutrophil degranulation : TAS:Reactome positive regulation of ERK1 and ERK2 cascade : IDA:BHF-UCL positive regulation of heterotypic cell-cell adhesion : IMP:UniProtKB positive regulation of monocyte aggregation : IMP:BHF-UCL positive regulation of peptidyl-serine phosphorylation : IDA:BHF-UCL positive regulation of peptidyl-tyrosine phosphorylation : IDA:BHF-UCL regulation of lamellipodium morphogenesis : IMP:UniProtKB T cell activation : IDA:UniProtKB wound healing, spreading of cells : IMP:UniProtKB

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^{(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.}
^{(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.}