Hepatocyte growth factor receptor (P16056)

Uniprot ID P16056
Protein Name Hepatocyte growth factor receptor
Gene Name Met
Species Mus musculus (Mouse)
Signal peptide(a) Y Secretome P(b) 0.0
Function Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells (By similarity). May regulate cortical bone osteogenesis (PubMed:26637977). .(Microbial infection) Acts as a receptor for Listeria monocytogenes internalin InlB, mediating entry of the pathogen into cells. {ECO:0000305|PubMed:11081636}.
GO - Molecular function
  • ATP binding : IEA:UniProtKB-KW
  • beta-catenin binding : ISO:MGI
  • hepatocyte growth factor-activated receptor activity : IDA:MGI
  • identical protein binding : ISO:MGI
  • phosphatidylinositol 3-kinase binding : ISO:MGI
  • phospholipase binding : ISO:MGI
  • protein kinase activity : IDA:MGI
  • protein phosphatase binding : ISO:MGI
  • protein tyrosine kinase activity : ISO:MGI
  • protein-containing complex binding : ISO:MGI
  • semaphorin receptor activity : IEA:InterPro
  • transmembrane receptor protein tyrosine kinase activity : IBA:GO_Central
GO - Biological process
  • activation of MAPK activity : IPI:MGI
  • adult behavior : IMP:MGI
  • brain development : IMP:MGI
  • branching morphogenesis of an epithelial tube : ISO:MGI
  • cardiac muscle cell development : IMP:MGI
  • cardiac muscle contraction : IMP:MGI
  • chemical synaptic transmission : IMP:CACAO
  • endothelial cell morphogenesis : ISO:MGI
  • establishment of skin barrier : ISO:MGI
  • excitatory postsynaptic potential : IMP:BHF-UCL
  • flagellated sperm motility : ISO:MGI
  • glucose homeostasis : IMP:MGI
  • hepatocyte growth factor receptor signaling pathway : IDA:MGI
  • liver development : IMP:MGI
  • modulation of chemical synaptic transmission : IMP:BHF-UCL
  • multicellular organism development : IBA:GO_Central
  • muscle cell migration : IMP:MGI
  • muscle organ development : IMP:MGI
  • myoblast proliferation : IMP:MGI
  • myotube differentiation : IMP:MGI
  • negative regulation of gene expression : IMP:MGI
  • negative regulation of guanyl-nucleotide exchange factor activity : ISO:MGI
  • negative regulation of hydrogen peroxide-mediated programmed cell death : ISO:MGI
  • negative regulation of peptidyl-threonine phosphorylation : ISO:MGI
  • negative regulation of Rho protein signal transduction : ISO:MGI
  • negative regulation of stress fiber assembly : ISO:MGI
  • negative regulation of thrombin-activated receptor signaling pathway : ISO:MGI
  • negative regulation of transcription by RNA polymerase II : ISO:MGI
  • negative regulation of transforming growth factor beta production : IMP:MGI
  • neuron differentiation : IBA:GO_Central
  • neuron migration : ISO:MGI
  • pancreas development : IBA:GO_Central
  • placenta development : IMP:MGI
  • positive chemotaxis : IMP:UniProtKB
  • positive regulation of dendrite morphogenesis : ISO:MGI
  • positive regulation of DNA replication : ISO:MGI
  • positive regulation of endothelial cell chemotaxis : ISS:UniProtKB
  • positive regulation of gene expression : ISO:MGI
  • positive regulation of glucose transmembrane transport : IMP:MGI
  • positive regulation of kinase activity : IBA:GO_Central
  • positive regulation of microtubule polymerization : ISO:MGI
  • positive regulation of mitotic nuclear division : ISO:MGI
  • positive regulation of neuron projection development : ISO:MGI
  • positive regulation of p38MAPK cascade : IMP:MGI
  • positive regulation of peptidyl-serine phosphorylation : ISO:MGI
  • positive regulation of peptidyl-threonine phosphorylation : ISO:MGI
  • positive regulation of protein kinase B signaling : IBA:GO_Central
  • positive regulation of transcription by RNA polymerase II : ISO:MGI
  • protein autophosphorylation : IDA:MGI
  • reactive oxygen species metabolic process : IMP:MGI
  • regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling : IMP:MGI
  • regulation of cellular response to oxidative stress : IMP:MGI
  • regulation of interleukin-6 production : IMP:MGI
  • semaphorin-plexin signaling pathway : IMP:UniProtKB
  • skeletal muscle tissue development : IMP:MGI
  • transmembrane receptor protein tyrosine kinase signaling pathway : IBA:GO_Central
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.