Galectin-1 (P16045)

Uniprot ID P16045
Protein Name Galectin-1
Gene Name Lgals1
Species Mus musculus (Mouse)
Signal peptide(a) N Secretome P(b) 0.698
Function Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis. .
GO - Molecular function
  • carbohydrate binding : IDA:MGI
  • galactose binding : NAS:UniProtKB
  • lactose binding : ISO:MGI
  • laminin binding : ISO:MGI
  • protein homodimerization activity : ISO:MGI
GO - Biological process
  • apoptotic process : IEA:UniProtKB-KW
  • cellular response to glucose stimulus : IEA:Ensembl
  • cellular response to organic cyclic compound : IEA:Ensembl
  • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules : NAS:UniProtKB
  • myoblast differentiation : IDA:MGI
  • negative regulation of cell-substrate adhesion : ISO:MGI
  • negative regulation of neuron projection development : ISO:MGI
  • plasma cell differentiation : IDA:MGI
  • positive regulation of erythrocyte aggregation : ISO:MGI
  • positive regulation of viral entry into host cell : ISO:MGI
  • response to axon injury : IEA:Ensembl
  • response to drug : IEA:Ensembl
  • response to isolation stress : IEA:Ensembl
  • T cell costimulation : IDA:MGI
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.