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P15943

Amyloid-like protein 2 (P15943)

Uniprot ID P15943
Protein Name Amyloid-like protein 2
Gene Name Aplp2
Species Rattus norvegicus (Rat)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b)
Function May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity). .
GO - Molecular function
  • heparin binding : IEA:InterPro
  • identical protein binding : ISO:RGD
  • serine-type endopeptidase inhibitor activity : IEA:UniProtKB-KW
  • transition metal ion binding : IEA:InterPro
GO - Biological process
  • cellular copper ion homeostasis : ISO:RGD
  • cholesterol metabolic process : ISO:RGD
  • extracellular matrix organization : ISO:RGD
  • forebrain development : ISO:RGD
  • locomotory behavior : ISO:RGD
  • mating behavior : ISO:RGD
  • midbrain development : ISO:RGD
  • neuromuscular process controlling balance : ISO:RGD
  • regulation of epidermal growth factor-activated receptor activity : ISO:RGD
  • regulation of protein binding : ISO:RGD
  • suckling behavior : ISO:RGD
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.