Nucleoside diphosphate kinase A (P15531)

Uniprot ID	P15531
Protein Name	Nucleoside diphosphate kinase A
Gene Name	NME1
Species	Homo sapiens (Human)

Signal peptide^(a)	N	Secretome P^(b)	0.58
Function	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair. .
GO - Molecular function	ATP binding : IDA:UniProtKB deoxyribonuclease activity : IDA:UniProtKB enzyme binding : IEA:Ensembl gamma-tubulin binding : IEA:Ensembl GTP binding : IDA:UniProtKB identical protein binding : IPI:IntAct intermediate filament binding : IEA:Ensembl magnesium ion binding : IDA:UniProtKB nucleoside diphosphate kinase activity : IDA:UniProtKB ribosomal small subunit binding : IPI:UniProtKB RNA binding : HDA:UniProtKB RNA polymerase II regulatory region sequence-specific DNA binding : IEA:Ensembl single-stranded DNA binding : IEA:Ensembl
GO - Biological process	cellular response to drug : IEA:Ensembl cellular response to fatty acid : IEA:Ensembl cellular response to glucose stimulus : IEA:Ensembl CTP biosynthetic process : IEA:InterPro endocytosis : IEA:UniProtKB-KW GTP biosynthetic process : IEA:InterPro hippocampus development : IEA:Ensembl lactation : IEA:Ensembl negative regulation of cell population proliferation : TAS:UniProtKB negative regulation of gene expression : IEA:Ensembl negative regulation of myeloid leukocyte differentiation : IEA:Ensembl nucleobase-containing small molecule interconversion : TAS:Reactome positive regulation of DNA binding : IDA:UniProtKB positive regulation of epithelial cell proliferation : IMP:HGNC-UCL positive regulation of neuron projection development : IEA:Ensembl purine nucleotide metabolic process : IBA:GO_Central pyrimidine nucleotide metabolic process : IBA:GO_Central regulation of apoptotic process : IBA:GO_Central response to amine : IEA:Ensembl response to cAMP : IEA:Ensembl response to testosterone : IEA:Ensembl UTP biosynthetic process : IEA:InterPro

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^{(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.}
^{(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.}