Beta-1,4-galactosyltransferase 1 (P15291)

Uniprot ID P15291
Protein Name Beta-1,4-galactosyltransferase 1
Gene Name B4GALT1
Species Homo sapiens (Human)
Signal peptide(a) N Secretome P(b) 0.818
Function [Beta-1,4-galactosyltransferase 1]: The Golgi complex form catalyzes the production of lactose in the lactating mammary gland and could also be responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. .[Processed beta-1,4-galactosyltransferase 1]: The cell surface form functions as a recognition molecule during a variety of cell to cell and cell to matrix interactions, as those occurring during development and egg fertilization, by binding to specific oligosaccharide ligands on opposing cells or in the extracellular matrix. {ECO:0000269|PubMed:16157350}.
GO - Molecular function
  • alpha-tubulin binding : IDA:UniProtKB
  • beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity : IDA:UniProtKB
  • beta-tubulin binding : IPI:UniProtKB
  • galactosyltransferase activity : NAS:UniProtKB
  • identical protein binding : IPI:UniProtKB
  • lactose synthase activity : IDA:UniProtKB
  • manganese ion binding : IDA:UniProtKB
  • N-acetyllactosamine synthase activity : IDA:UniProtKB
  • UDP-galactosyltransferase activity : IDA:UniProtKB
GO - Biological process
  • acute inflammatory response : IEA:Ensembl
  • angiogenesis involved in wound healing : IEA:Ensembl
  • binding of sperm to zona pellucida : TAS:Reactome
  • cell adhesion : IEA:Ensembl
  • development of secondary sexual characteristics : IEA:Ensembl
  • epithelial cell development : IEA:Ensembl
  • extracellular matrix organization : IEA:Ensembl
  • galactose metabolic process : IEA:Ensembl
  • keratan sulfate biosynthetic process : TAS:Reactome
  • lactose biosynthetic process : TAS:Reactome
  • leukocyte migration : IEA:Ensembl
  • negative regulation of cell population proliferation : IEA:Ensembl
  • neutrophil degranulation : TAS:Reactome
  • oligosaccharide biosynthetic process : IDA:UniProtKB
  • penetration of zona pellucida : IEA:Ensembl
  • positive regulation of apoptotic process : IEA:Ensembl
  • positive regulation of epithelial cell proliferation involved in wound healing : IEA:Ensembl
  • protein N-linked glycosylation : IDA:UniProtKB
  • regulation of acrosome reaction : IEA:Ensembl
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.