Home Proteins Experiments Diseases Interactions Tutorial
Home
/
Proteins
/
P15087

Carboxypeptidase E (P15087)

Uniprot ID P15087
Protein Name Carboxypeptidase E
Gene Name Cpe
Species Rattus norvegicus (Rat)
Basic Information Experiments (1) Disease (5) Interactions
Signal peptide(a) Y Secretome P(b)
Function Sorting receptor that directs prohormones to the regulated secretory pathway. Acts also as a prohormone processing enzyme in neuro/endocrine cells, removing dibasic residues from the C-terminal end of peptide hormone precursors after initial endoprotease cleavage. .
GO - Molecular function
  • carboxypeptidase activity : IDA:RGD
  • cell adhesion molecule binding : ISO:RGD
  • cobalt ion binding : IMP:RGD
  • metallocarboxypeptidase activity : IBA:GO_Central
  • neurexin family protein binding : ISO:RGD
  • protein domain specific binding : IDA:RGD
  • zinc ion binding : IEA:InterPro
GO - Biological process
  • cardiac left ventricle morphogenesis : ISO:RGD
  • enkephalin processing : IDA:RGD
  • insulin processing : IDA:RGD
  • negative regulation of branching morphogenesis of a nerve : IMP:RGD
  • peptide catabolic process : IDA:RGD
  • peptide hormone processing : TAS:RGD
  • peptide hormone secretion : ISO:RGD
  • peptide metabolic process : IDA:RGD
  • protein localization to membrane : ISO:RGD
  • protein localization to secretory granule : ISO:RGD
  • protein processing : IDA:RGD
  • Wnt signaling pathway : ISO:RGD
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.