Annexin A5 (P14668)

Uniprot ID P14668
Protein Name Annexin A5
Gene Name Anxa5
Species Rattus norvegicus (Rat)
Signal peptide(a) N Secretome P(b)
Function This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.
GO - Molecular function
  • calcium ion binding : IEA:InterPro
  • calcium transmembrane transporter activity, phosphorylative mechanism : IDA:RGD
  • calcium-dependent phospholipid binding : IDA:RGD
  • heparin binding : IBA:GO_Central
  • identical protein binding : IPI:RGD
  • peptide hormone binding : IDA:RGD
  • receptor tyrosine kinase binding : IPI:RGD
GO - Biological process
  • blood coagulation : IEA:UniProtKB-KW
  • cellular response to gonadotropin-releasing hormone : IMP:RGD
  • cellular response to lead ion : IEP:RGD
  • negative regulation of blood coagulation : IDA:RGD
  • negative regulation of prolactin secretion : IMP:RGD
  • negative regulation of sequestering of calcium ion : IBA:GO_Central
  • positive regulation of apoptotic process : IDA:RGD
  • regulation of flagellated sperm motility : IDA:RGD
  • response to calcium ion : IDA:RGD
  • response to organic substance : ISO:RGD
  • response to thyroid hormone : IEP:RGD
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.