| Signal peptide(a) |
Y |
Secretome P(b) |
0.121 |
| Function |
Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity). . |
| GO - Molecular function |
- androgen receptor binding : ISO:MGI
- calcium ion binding : IDA:UniProtKB
- carbohydrate binding : IDA:UniProtKB
- hormone binding : ISO:MGI
- integrin binding : ISO:MGI
- iron ion binding : ISO:MGI
- mRNA binding : IDA:BHF-UCL
- peptide binding : ISO:MGI
- ubiquitin protein ligase binding : ISO:MGI
- unfolded protein binding : ISO:MGI
|
| GO - Biological process |
- cardiac muscle cell differentiation : IEA:Ensembl
- cellular response to lithium ion : IEA:Ensembl
- cellular response to organic substance : IEA:Ensembl
- cellular senescence : IMP:BHF-UCL
- chaperone-mediated protein folding : ISO:MGI
- cortical actin cytoskeleton organization : IDA:MGI
- negative regulation of cell cycle arrest : ISO:MGI
- negative regulation of intracellular steroid hormone receptor signaling pathway : ISO:MGI
- negative regulation of neuron differentiation : ISO:MGI
- negative regulation of retinoic acid receptor signaling pathway : ISO:MGI
- negative regulation of transcription by RNA polymerase II : ISO:MGI
- negative regulation of transcription, DNA-templated : ISO:MGI
- negative regulation of translation : ISO:MGI
- negative regulation of trophoblast cell migration : ISO:MGI
- peptide antigen assembly with MHC class I protein complex : IMP:BHF-UCL
- positive regulation of cell cycle : IMP:BHF-UCL
- positive regulation of cell proliferation : ISO:MGI
- positive regulation of dendritic cell chemotaxis : ISO:MGI
- positive regulation of endothelial cell migration : ISO:MGI
- positive regulation of gene expression : IMP:UniProtKB
- positive regulation of NIK/NF-kappaB signaling : IMP:MGI
- positive regulation of phagocytosis : IMP:BHF-UCL
- positive regulation of substrate adhesion-dependent cell spreading : ISO:MGI
- protein export from nucleus : ISO:MGI
- protein localization to nucleus : IMP:UniProtKB
- protein stabilization : IDA:UniProtKB
- regulation of meiotic nuclear division : IDA:MGI
- response to drug : IEA:Ensembl
- response to estradiol : IEA:Ensembl
- response to testosterone : IEA:Ensembl
- spermatogenesis : IEA:Ensembl
|