| Signal peptide(a) |
N |
Secretome P(b) |
0.737 |
| Function |
Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA (By similarity). Enables malignant tumor cells to penetrate laminin tissue and vessel barriers. Activates precursor thymic anti-OFA/iLRP specific cytotoxic T-cell. May induce CD8 T-suppressor cells secreting IL-10. . |
| GO - Molecular function |
- laminin binding : IDA:MGI
- laminin receptor activity : IEA:InterPro
- ribosome binding : ISO:MGI
- structural constituent of ribosome : IBA:GO_Central
|
| GO - Biological process |
- cell-cell adhesion : ISO:MGI
- endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) : IBA:GO_Central
- endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) : IBA:GO_Central
- epithelial cell differentiation : IEA:Ensembl
- ribosomal small subunit assembly : IBA:GO_Central
- rRNA export from nucleus : IBA:GO_Central
- translation : IBA:GO_Central
|