| Signal peptide(a) |
N |
Secretome P(b) |
0.925 |
| Function |
Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity. . |
| GO - Molecular function |
- chemoattractant activity : IDA:BHF-UCL
- cytokine activity : IDA:UniProtKB
- cytokine receptor binding : IDA:BHF-UCL
- dopachrome isomerase activity : IDA:UniProtKB
- identical protein binding : IPI:IntAct
- phenylpyruvate tautomerase activity : IDA:BHF-UCL
- protease binding : IEA:Ensembl
- signaling receptor binding : IPI:BHF-UCL
|
| GO - Biological process |
- carboxylic acid metabolic process : IDA:BHF-UCL
- cell aging : IEA:Ensembl
- cell proliferation : IDA:UniProtKB
- cell surface receptor signaling pathway : IDA:UniProtKB
- DNA damage response, signal transduction by p53 class mediator : IEA:Ensembl
- inflammatory response : IEA:UniProtKB-KW
- innate immune response : IEA:UniProtKB-KW
- interleukin-12-mediated signaling pathway : TAS:Reactome
- leukocyte migration : TAS:Reactome
- negative regulation of apoptotic process : IDA:UniProtKB
- negative regulation of cell aging : IDA:BHF-UCL
- negative regulation of cell cycle arrest : IDA:BHF-UCL
- negative regulation of cellular protein metabolic process : IEA:Ensembl
- negative regulation of DNA damage response, signal transduction by p53 class mediator : IDA:BHF-UCL
- negative regulation of gene expression : IDA:BHF-UCL
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator : IDA:BHF-UCL
- negative regulation of macrophage chemotaxis : IDA:BHF-UCL
- negative regulation of mature B cell apoptotic process : IEA:Ensembl
- negative regulation of myeloid cell apoptotic process : IEA:Ensembl
- neutrophil degranulation : TAS:Reactome
- positive regulation of arachidonic acid secretion : IEA:Ensembl
- positive regulation of B cell proliferation : IDA:BHF-UCL
- positive regulation of chemokine (C-X-C motif) ligand 2 production : IEA:Ensembl
- positive regulation of cytokine secretion : IDA:BHF-UCL
- positive regulation of ERK1 and ERK2 cascade : IDA:BHF-UCL
- positive regulation of fibroblast proliferation : IDA:BHF-UCL
- positive regulation of lipopolysaccharide-mediated signaling pathway : IEA:Ensembl
- positive regulation of MAP kinase activity : IEA:Ensembl
- positive regulation of myeloid leukocyte cytokine production involved in immune response : IEA:Ensembl
- positive regulation of peptidyl-serine phosphorylation : IDA:BHF-UCL
- positive regulation of peptidyl-tyrosine phosphorylation : IDA:BHF-UCL
- positive regulation of phosphorylation : IDA:BHF-UCL
- positive regulation of prostaglandin secretion involved in immune response : IEA:Ensembl
- positive regulation of protein kinase A signaling : IDA:BHF-UCL
- positive regulation of tumor necrosis factor production : IDA:BHF-UCL
- prostaglandin biosynthetic process : IDA:UniProtKB
- protein homotrimerization : IPI:UniProtKB
- regulation of macrophage activation : NAS:UniProtKB
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