Complement C1q subcomponent subunit B (P14106)

Uniprot ID P14106
Protein Name Complement C1q subcomponent subunit B
Gene Name C1qb
Species Mus musculus (Mouse)
Signal peptide(a) Y Secretome P(b) 0.879
Function C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.
GO - Molecular function
  • protein homodimerization activity : IDA:MGI
GO - Biological process
  • complement activation, classical pathway : IEA:UniProtKB-KW
  • innate immune response : IEA:UniProtKB-KW
  • inner ear development : IDA:MGI
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.