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P14097

C-C motif chemokine 4 (P14097)

Uniprot ID P14097
Protein Name C-C motif chemokine 4
Gene Name Ccl4
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b) 0.972
Function Monokine with inflammatory and chemokinetic properties.
GO - Molecular function
  • CCR chemokine receptor binding : IBA:GO_Central
  • CCR1 chemokine receptor binding : ISO:MGI
  • CCR5 chemokine receptor binding : ISO:MGI
  • chemokine activity : ISO:MGI
  • identical protein binding : ISO:MGI
GO - Biological process
  • cellular response to drug : IDA:MGI
  • cellular response to interferon-gamma : IBA:GO_Central
  • cellular response to interleukin-1 : IBA:GO_Central
  • cellular response to tumor necrosis factor : IBA:GO_Central
  • chemokine-mediated signaling pathway : IBA:GO_Central
  • G-protein coupled receptor signaling pathway : IBA:GO_Central
  • inflammatory response : ISO:MGI
  • leukocyte chemotaxis : ISO:MGI
  • lymphocyte chemotaxis : IBA:GO_Central
  • monocyte chemotaxis : IBA:GO_Central
  • negative regulation by host of viral transcription : ISO:MGI
  • neutrophil chemotaxis : IBA:GO_Central
  • positive regulation of calcium ion transport : ISO:MGI
  • positive regulation of calcium-mediated signaling : ISO:MGI
  • positive regulation of ERK1 and ERK2 cascade : IBA:GO_Central
  • positive regulation of GTPase activity : IBA:GO_Central
  • positive regulation of natural killer cell chemotaxis : ISO:MGI
  • positive regulation of tumor necrosis factor production : ISO:MGI
  • positive regulation of vascular permeability : ISO:MGI
  • response to toxic substance : ISO:MGI
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.