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P14095

Growth-regulated alpha protein (P14095)

Uniprot ID P14095
Protein Name Growth-regulated alpha protein
Gene Name Cxcl1
Species Rattus norvegicus (Rat)
Basic Information Experiments (4) Disease (4) Interactions
Signal peptide(a) Y Secretome P(b)
Function Has chemotactic activity for neutrophils. Contributes to neutrophil activation during inflammation.
GO - Molecular function
  • chemokine activity : IDA:RGD
  • CXCR chemokine receptor binding : IBA:GO_Central
  • growth factor activity : IEA:UniProtKB-KW
GO - Biological process
  • acute inflammatory response : IDA:RGD
  • antimicrobial humoral immune response mediated by antimicrobial peptide : ISO:RGD
  • cellular response to lipopolysaccharide : IBA:GO_Central
  • chemokine-mediated signaling pathway : IBA:GO_Central
  • immune response : IBA:GO_Central
  • inflammatory response : IBA:GO_Central
  • killing of cells of other organism : ISO:RGD
  • leukocyte chemotaxis : IBA:GO_Central
  • neutrophil chemotaxis : IDA:RGD
  • positive regulation of cytosolic calcium ion concentration : IDA:RGD
  • positive regulation of hematopoietic stem cell proliferation : ISO:RGD
  • positive regulation of neutrophil mediated killing of fungus : ISO:RGD
  • positive regulation of potassium ion transport : IDA:RGD
  • positive regulation of sodium ion transport : IDA:RGD
  • positive regulation of superoxide anion generation : ISO:RGD
  • response to amphetamine : IEP:RGD
  • response to estradiol : IEP:RGD
  • response to gamma radiation : IEP:RGD
  • response to glucocorticoid : IEP:RGD
  • response to heat : IEP:RGD
  • response to lipopolysaccharide : IEP:RGD
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.