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P13635

Ceruloplasmin (P13635)

Uniprot ID P13635
Protein Name Ceruloplasmin
Gene Name Cp
Species Rattus norvegicus (Rat)
Basic Information Experiments (3) Disease (15) Interactions
Signal peptide(a) Y Secretome P(b) 0.0
Function Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. May also play a role in fetal lung development or pulmonary antioxidant defense. involved in iron transport across the cell membrane (By similarity). Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. .
GO - Molecular function
  • chaperone binding : ISO:RGD
  • copper ion binding : IDA:RGD
  • ferroxidase activity : ISO:RGD
GO - Biological process
  • aging : IEP:RGD
  • cellular iron ion homeostasis : TAS:RGD
  • iron ion homeostasis : IBA:GO_Central
  • iron ion transport : IBA:GO_Central
  • liver development : IEP:RGD
  • lung development : IEP:RGD
  • plasma membrane copper ion transport : TAS:RGD
  • response to copper ion : IDA:RGD
  • response to nutrient : IEP:RGD
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.