Intercellular adhesion molecule 1 (P13597)

Uniprot ID P13597
Protein Name Intercellular adhesion molecule 1
Gene Name Icam1
Species Mus musculus (Mouse)
Signal peptide(a) Y Secretome P(b) 0.361
Function ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (By similarity). .
GO - Molecular function
  • integrin binding : ISO:MGI
  • protein-containing complex binding : ISO:MGI
GO - Biological process
  • acute inflammatory response to antigenic stimulus : ISO:MGI
  • adhesion of symbiont to host : ISO:MGI
  • cell adhesion : IDA:MGI
  • cell adhesion mediated by integrin : IDA:MGI
  • cell-cell adhesion : ISO:MGI
  • cellular response to glucose stimulus : IDA:MGI
  • cellular response to leukemia inhibitory factor : IEP:MGI
  • establishment of endothelial barrier : ISO:MGI
  • establishment of endothelial intestinal barrier : ISO:MGI
  • establishment of Sertoli cell barrier : ISO:MGI
  • leukocyte cell-cell adhesion : IMP:MGI
  • membrane to membrane docking : IEA:Ensembl
  • negative regulation of calcium ion transport : ISO:MGI
  • negative regulation of endothelial cell apoptotic process : ISO:MGI
  • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors : ISO:MGI
  • positive regulation of actin filament polymerization : ISO:MGI
  • positive regulation of cellular extravasation : ISO:MGI
  • positive regulation of ERK1 and ERK2 cascade : ISO:MGI
  • positive regulation of GTPase activity : ISO:MGI
  • positive regulation of leukocyte adhesion to vascular endothelial cell : ISO:MGI
  • positive regulation of NF-kappaB transcription factor activity : ISO:MGI
  • positive regulation of nitric oxide biosynthetic process : ISO:MGI
  • positive regulation of peptidyl-tyrosine phosphorylation : ISO:MGI
  • positive regulation of vasoconstriction : ISO:MGI
  • receptor-mediated virion attachment to host cell : ISO:MGI
  • regulation of cell adhesion : IDA:MGI
  • regulation of cell shape : ISO:MGI
  • regulation of ruffle assembly : IDA:MGI
  • sensory perception of sound : ISO:MGI
  • T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell : ISO:MGI
  • T cell antigen processing and presentation : IDA:MGI
  • T cell extravasation : IMP:MGI
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.