| Signal peptide(a) |
Y |
Secretome P(b) |
0.361 |
| Function |
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (By similarity). . |
| GO - Molecular function |
- integrin binding : ISO:MGI
- protein-containing complex binding : ISO:MGI
|
| GO - Biological process |
- acute inflammatory response to antigenic stimulus : ISO:MGI
- adhesion of symbiont to host : ISO:MGI
- cell adhesion : IDA:MGI
- cell adhesion mediated by integrin : IDA:MGI
- cell-cell adhesion : ISO:MGI
- cellular response to glucose stimulus : IDA:MGI
- cellular response to leukemia inhibitory factor : IEP:MGI
- establishment of endothelial barrier : ISO:MGI
- establishment of endothelial intestinal barrier : ISO:MGI
- establishment of Sertoli cell barrier : ISO:MGI
- leukocyte cell-cell adhesion : IMP:MGI
- membrane to membrane docking : IEA:Ensembl
- negative regulation of calcium ion transport : ISO:MGI
- negative regulation of endothelial cell apoptotic process : ISO:MGI
- negative regulation of extrinsic apoptotic signaling pathway via death domain receptors : ISO:MGI
- positive regulation of actin filament polymerization : ISO:MGI
- positive regulation of cellular extravasation : ISO:MGI
- positive regulation of ERK1 and ERK2 cascade : ISO:MGI
- positive regulation of GTPase activity : ISO:MGI
- positive regulation of leukocyte adhesion to vascular endothelial cell : ISO:MGI
- positive regulation of NF-kappaB transcription factor activity : ISO:MGI
- positive regulation of nitric oxide biosynthetic process : ISO:MGI
- positive regulation of peptidyl-tyrosine phosphorylation : ISO:MGI
- positive regulation of vasoconstriction : ISO:MGI
- receptor-mediated virion attachment to host cell : ISO:MGI
- regulation of cell adhesion : IDA:MGI
- regulation of cell shape : ISO:MGI
- regulation of ruffle assembly : IDA:MGI
- sensory perception of sound : ISO:MGI
- T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell : ISO:MGI
- T cell antigen processing and presentation : IDA:MGI
- T cell extravasation : IMP:MGI
|