| Signal peptide(a) |
Y |
Secretome P(b) |
0.961 |
| Function |
Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. |
| GO - Molecular function |
- CCR2 chemokine receptor binding : ISS:BHF-UCL
- chemokine activity : IBA:GO_Central
- protein kinase activity : TAS:ProtInc
- signaling receptor binding : TAS:ProtInc
|
| GO - Biological process |
- angiogenesis : TAS:BHF-UCL
- animal organ morphogenesis : TAS:ProtInc
- astrocyte cell migration : IDA:BHF-UCL
- cell adhesion : TAS:ProtInc
- cell surface receptor signaling pathway : TAS:ProtInc
- cellular homeostasis : TAS:BHF-UCL
- cellular response to fibroblast growth factor stimulus : IEP:UniProtKB
- cellular response to interferon-gamma : IEP:UniProtKB
- cellular response to interleukin-1 : IEP:UniProtKB
- cellular response to lipopolysaccharide : ISS:BHF-UCL
- cellular response to organic cyclic compound : IDA:UniProtKB
- cellular response to tumor necrosis factor : IEP:UniProtKB
- chemokine-mediated signaling pathway : IBA:GO_Central
- chemotaxis : TAS:ProtInc
- cytokine-mediated signaling pathway : IDA:BHF-UCL
- cytoskeleton organization : IDA:UniProtKB
- G-protein coupled receptor signaling pathway : TAS:ProtInc
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger : TAS:ProtInc
- helper T cell extravasation : ISS:BHF-UCL
- humoral immune response : TAS:ProtInc
- inflammatory response : IDA:UniProtKB
- JAK-STAT cascade : TAS:ProtInc
- lipopolysaccharide-mediated signaling pathway : IDA:UniProtKB
- macrophage chemotaxis : IDA:BHF-UCL
- MAPK cascade : IMP:UniProtKB
- monocyte chemotaxis : IDA:BHF-UCL
- negative regulation of G1/S transition of mitotic cell cycle : IMP:BHF-UCL
- negative regulation of glial cell apoptotic process : IDA:UniProtKB
- negative regulation of natural killer cell chemotaxis : IDA:UniProtKB
- negative regulation of neuron apoptotic process : IDA:UniProtKB
- negative regulation of vascular endothelial cell proliferation : IMP:BHF-UCL
- neutrophil chemotaxis : IBA:GO_Central
- PERK-mediated unfolded protein response : TAS:Reactome
- positive regulation of apoptotic cell clearance : ISS:BHF-UCL
- positive regulation of calcium ion import : IDA:BHF-UCL
- positive regulation of endothelial cell apoptotic process : IMP:BHF-UCL
- positive regulation of ERK1 and ERK2 cascade : IBA:GO_Central
- positive regulation of GTPase activity : IBA:GO_Central
- positive regulation of nitric-oxide synthase biosynthetic process : ISS:BHF-UCL
- positive regulation of T cell activation : ISS:BHF-UCL
- protein kinase B signaling : IMP:UniProtKB
- protein phosphorylation : TAS:ProtInc
- regulation of cell shape : IDA:UniProtKB
- response to bacterium : NAS:BHF-UCL
- signal transduction : NAS:ProtInc
- viral genome replication : TAS:ProtInc
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