Nucleolin (P13383)

Uniprot ID P13383
Protein Name Nucleolin
Gene Name Ncl
Species Rattus norvegicus (Rat)
Signal peptide(a) N Secretome P(b)
Function Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats (By similarity). .
GO - Molecular function
  • calcium ion binding : IDA:RGD
  • DNA topoisomerase binding : ISO:RGD
  • ErbB-4 class receptor binding : IPI:RGD
  • histone binding : IDA:RGD
  • identical protein binding : ISO:RGD
  • laminin binding : IDA:RGD
  • mRNA 5'-UTR binding : ISO:RGD
  • protein C-terminus binding : ISO:RGD
  • RNA binding : IDA:RGD
  • rRNA primary transcript binding : IDA:RGD
  • selenocysteine insertion sequence binding : IDA:RGD
  • sequence-specific DNA binding : IDA:RGD
  • signaling receptor binding : IDA:RGD
  • single-stranded DNA binding : IDA:RGD
  • telomeric DNA binding : ISS:UniProtKB
GO - Biological process
  • angiogenesis : ISO:RGD
  • cellular response to epidermal growth factor stimulus : ISO:RGD
  • cellular response to leukemia inhibitory factor : ISO:RGD
  • cellular response to lipopolysaccharide : IMP:RGD
  • endocytosis : IMP:RGD
  • liver regeneration : IEP:RGD
  • negative regulation of apoptotic process : IMP:RGD
  • negative regulation of translation : ISO:RGD
  • positive regulation of interleukin-6 secretion : IMP:RGD
  • positive regulation of mRNA splicing, via spliceosome : IBA:GO_Central
  • positive regulation of transcription by RNA polymerase II : ISO:RGD
  • positive regulation of transcription of nucleolar large rRNA by RNA polymerase I : ISO:RGD
  • positive regulation of tumor necrosis factor production : IMP:RGD
  • regulation of RNA metabolic process : IBA:GO_Central
  • regulation of rRNA processing : IDA:RGD
  • spermatogenesis : IEP:RGD
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.