| Signal peptide(a) |
N |
Secretome P(b) |
|
| Function |
Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats (By similarity). . |
| GO - Molecular function |
- calcium ion binding : IDA:RGD
- DNA topoisomerase binding : ISO:RGD
- ErbB-4 class receptor binding : IPI:RGD
- histone binding : IDA:RGD
- identical protein binding : ISO:RGD
- laminin binding : IDA:RGD
- mRNA 5'-UTR binding : ISO:RGD
- protein C-terminus binding : ISO:RGD
- RNA binding : IDA:RGD
- rRNA primary transcript binding : IDA:RGD
- selenocysteine insertion sequence binding : IDA:RGD
- sequence-specific DNA binding : IDA:RGD
- signaling receptor binding : IDA:RGD
- single-stranded DNA binding : IDA:RGD
- telomeric DNA binding : ISS:UniProtKB
|
| GO - Biological process |
- angiogenesis : ISO:RGD
- cellular response to epidermal growth factor stimulus : ISO:RGD
- cellular response to leukemia inhibitory factor : ISO:RGD
- cellular response to lipopolysaccharide : IMP:RGD
- endocytosis : IMP:RGD
- liver regeneration : IEP:RGD
- negative regulation of apoptotic process : IMP:RGD
- negative regulation of translation : ISO:RGD
- positive regulation of interleukin-6 secretion : IMP:RGD
- positive regulation of mRNA splicing, via spliceosome : IBA:GO_Central
- positive regulation of transcription by RNA polymerase II : ISO:RGD
- positive regulation of transcription of nucleolar large rRNA by RNA polymerase I : ISO:RGD
- positive regulation of tumor necrosis factor production : IMP:RGD
- regulation of RNA metabolic process : IBA:GO_Central
- regulation of rRNA processing : IDA:RGD
- spermatogenesis : IEP:RGD
|