| Signal peptide(a) |
Y |
Secretome P(b) |
0.471 |
| Function |
Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis. |
| GO - Molecular function |
- actin binding : ISO:MGI
- actin filament binding : IEA:InterPro
- calcium ion binding : ISO:MGI
- myosin II binding : ISO:MGI
|
| GO - Biological process |
- actin filament capping : IDA:UniProtKB
- actin filament polymerization : IDA:UniProtKB
- actin filament reorganization : ISO:MGI
- actin filament severing : IMP:UniProtKB
- actin nucleation : IEA:InterPro
- actin polymerization or depolymerization : ISO:MGI
- aging : IEA:Ensembl
- amyloid fibril formation : ISO:MGI
- apoptotic process : ISO:MGI
- barbed-end actin filament capping : IEA:InterPro
- cellular response to cadmium ion : ISO:MGI
- cellular response to interferon-gamma : IDA:MGI
- cilium assembly : ISS:UniProtKB
- hepatocyte apoptotic process : ISO:MGI
- negative regulation of viral entry into host cell : ISO:MGI
- oligodendrocyte development : IEA:Ensembl
- phagocytosis, engulfment : IMP:UniProtKB
- phosphatidylinositol-mediated signaling : ISO:MGI
- positive regulation of actin nucleation : ISO:MGI
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway : ISO:MGI
- positive regulation of gene expression : ISO:MGI
- positive regulation of keratinocyte apoptotic process : ISO:MGI
- positive regulation of protein processing in phagocytic vesicle : IMP:UniProtKB
- protein destabilization : ISO:MGI
- regulation of cell adhesion : ISO:MGI
- regulation of establishment of T cell polarity : ISO:MGI
- regulation of plasma membrane raft polarization : ISO:MGI
- regulation of podosome assembly : ISO:MGI
- regulation of receptor clustering : ISO:MGI
- renal protein absorption : ISO:MGI
- response to ethanol : IEA:Ensembl
- response to folic acid : IEA:Ensembl
- sequestering of actin monomers : ISO:MGI
- striated muscle atrophy : ISO:MGI
- tissue regeneration : IEA:Ensembl
- vesicle-mediated transport : IMP:MGI
|