Neuroendocrine protein 7B2 (P12961)

Uniprot ID P12961
Protein Name Neuroendocrine protein 7B2
Gene Name Scg5
Species Mus musculus (Mouse)
Signal peptide(a) Y Secretome P(b) 0.873
Function Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro. .
GO - Molecular function
  • enzyme inhibitor activity : IDA:UniProtKB
  • unfolded protein binding : ISS:UniProtKB
GO - Biological process
  • intracellular protein transport : IDA:UniProtKB
  • neuropeptide signaling pathway : IEA:UniProtKB-KW
  • peptide hormone processing : IDA:UniProtKB
  • regulation of hormone secretion : IDA:UniProtKB
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.