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P12850

Growth-regulated alpha protein (P12850)

Uniprot ID P12850
Protein Name Growth-regulated alpha protein
Gene Name Cxcl1
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (4) Interactions
Signal peptide(a) Y Secretome P(b) 0.904
Function Has chemotactic activity for neutrophils. Contributes to neutrophil activation during inflammation (By similarity). Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. KC(5-72) shows a highly enhanced hematopoietic activity. .
GO - Molecular function
  • chemokine activity : ISO:MGI
  • CXCR chemokine receptor binding : IBA:GO_Central
  • growth factor activity : IEA:UniProtKB-KW
GO - Biological process
  • acute inflammatory response : ISO:MGI
  • chemokine-mediated signaling pathway : IBA:GO_Central
  • G-protein coupled receptor signaling pathway : IBA:GO_Central
  • immune response : IBA:GO_Central
  • inflammatory response : IBA:GO_Central
  • neutrophil chemotaxis : ISO:MGI
  • positive regulation of cytosolic calcium ion concentration : ISO:MGI
  • positive regulation of hematopoietic stem cell proliferation : IDA:UniProtKB
  • positive regulation of neutrophil chemotaxis : IBA:GO_Central
  • positive regulation of neutrophil mediated killing of fungus : IDA:UniProtKB
  • positive regulation of potassium ion transport : ISO:MGI
  • positive regulation of sodium ion transport : ISO:MGI
  • positive regulation of superoxide anion generation : IDA:UniProtKB
  • response to lipopolysaccharide : IBA:GO_Central
  • response to molecule of bacterial origin : ISO:MGI
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.