| Signal peptide(a) |
N |
Secretome P(b) |
|
| Function |
Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation. |
| GO - Molecular function |
- ferric iron binding : IDA:RGD
- ferric iron transmembrane transporter activity : IEA:InterPro
- ferrous iron binding : ISO:RGD
- iron chaperone activity : ISO:RGD
- transferrin receptor binding : ISO:RGD
|
| GO - Biological process |
- actin filament organization : ISO:RGD
- activation of JUN kinase activity : ISO:RGD
- acute-phase response : IEP:RGD
- apoptotic process : ISS:UniProtKB
- cellular iron ion homeostasis : TAS:RGD
- cellular response to cAMP : IEP:UniProtKB
- cellular response to follicle-stimulating hormone stimulus : IEP:UniProtKB
- cellular response to iron ion : ISO:RGD
- ERK1 and ERK2 cascade : ISO:RGD
- iron ion transport : IDA:RGD
- osteoclast differentiation : ISO:RGD
- positive regulation of bone resorption : ISO:RGD
- positive regulation of cell motility : ISO:RGD
- positive regulation of myelination : IDA:RGD
- positive regulation of oligodendrocyte progenitor proliferation : IDA:RGD
- positive regulation of phosphorylation : ISO:RGD
- positive regulation of receptor-mediated endocytosis : ISO:RGD
- positive regulation of transcription, DNA-templated : ISO:RGD
- regulation of iron ion transport : ISO:RGD
- response to bacterium : ISO:RGD
- response to hypoxia : IEP:RGD
- response to lead ion : IEP:RGD
- response to organic cyclic compound : IEP:RGD
- SMAD protein signal transduction : ISO:RGD
|