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P12032

Metalloproteinase inhibitor 1 (P12032)

Uniprot ID P12032
Protein Name Metalloproteinase inhibitor 1
Gene Name Timp1
Species Mus musculus (Mouse)
Basic Information Experiments (5) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b) 0.872
Function Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14 (By similarity). Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. .
GO - Molecular function
  • cytokine activity : ISS:UniProtKB
  • growth factor activity : IEA:UniProtKB-KW
  • metalloendopeptidase inhibitor activity : ISS:UniProtKB
  • protease binding : ISO:MGI
  • zinc ion binding : ISO:MGI
GO - Biological process
  • cell activation : ISO:MGI
  • connective tissue replacement involved in inflammatory response wound healing : IDA:MGI
  • negative regulation of apoptotic process : ISO:MGI
  • negative regulation of catalytic activity : ISS:UniProtKB
  • negative regulation of endopeptidase activity : ISS:UniProtKB
  • negative regulation of membrane protein ectodomain proteolysis : ISO:MGI
  • negative regulation of metallopeptidase activity : ISO:MGI
  • negative regulation of trophoblast cell migration : ISO:MGI
  • positive regulation of cell proliferation : ISS:UniProtKB
  • regulation of integrin-mediated signaling pathway : ISS:UniProtKB
  • response to cytokine : IBA:GO_Central
  • response to hormone : IBA:GO_Central
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.