Home Proteins Experiments Diseases Interactions Tutorial
Home
/
Proteins
/
P11983

T-complex protein 1 subunit alpha (P11983)

Uniprot ID P11983
Protein Name T-complex protein 1 subunit alpha
Gene Name Tcp1
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.62
Function Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity). .
GO - Molecular function
  • ATP binding : IEA:UniProtKB-KW
  • protein binding involved in protein folding : IBA:GO_Central
  • ubiquitin protein ligase binding : ISO:MGI
  • unfolded protein binding : IBA:GO_Central
GO - Biological process
  • 'de novo' protein folding : IBA:GO_Central
  • binding of sperm to zona pellucida : IDA:MGI
  • chaperone-mediated protein folding : IBA:GO_Central
  • positive regulation of establishment of protein localization to telomere : ISO:MGI
  • positive regulation of telomerase activity : ISO:MGI
  • positive regulation of telomerase RNA localization to Cajal body : ISO:MGI
  • positive regulation of telomere maintenance via telomerase : ISO:MGI
  • protein stabilization : ISO:MGI
  • regulation of macrophage apoptotic process : IMP:MGI
  • scaRNA localization to Cajal body : ISO:MGI
  • toxin transport : IMP:MGI
  • translocation of peptides or proteins into host cell cytoplasm : IMP:MGI
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.