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P11881

Inositol 1,4,5-trisphosphate receptor type 1 (P11881 )

Uniprot ID P11881
Protein Name Inositol 1,4,5-trisphosphate receptor type 1
Gene Name Itpr1
Species Mus musculus (Mouse)
Basic Information Experiments (0) Disease (0) Interactions
Signal peptide(a) N Secretome P(b)
Function Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 (PubMed:23542070). Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways. .
GO - Molecular function
  • calcium channel inhibitor activity : ISO:MGI
  • calcium ion binding : IBA:GO_Central
  • calcium-release channel activity : IDA:UniProtKB
  • identical protein binding : ISO:MGI
  • inositol 1,4,5 trisphosphate binding : IBA:GO_Central
  • inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels : IMP:SynGO
  • inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity : IDA:UniProtKB
  • ion channel binding : ISO:MGI
  • phosphatidylinositol binding : IDA:UniProtKB
  • protein C-terminus binding : ISO:MGI
  • protein phosphatase binding : ISO:MGI
  • protein-containing complex binding : ISO:MGI
GO - Biological process
  • calcium ion transport : IDA:MGI
  • cellular response to cAMP : ISO:MGI
  • endoplasmic reticulum calcium ion homeostasis : IGI:MGI
  • epithelial fluid transport : IDA:UniProtKB
  • intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress : IMP:UniProtKB
  • liver regeneration : ISO:MGI
  • negative regulation of calcium-mediated signaling : ISO:MGI
  • negative regulation of neuron death : ISO:MGI
  • positive regulation of apoptotic process : ISO:MGI
  • positive regulation of calcium ion transport : ISO:MGI
  • positive regulation of cytosolic calcium ion concentration : ISO:MGI
  • positive regulation of hepatocyte proliferation : ISO:MGI
  • positive regulation of neuron projection development : ISO:MGI
  • post-embryonic development : IMP:MGI
  • release of sequestered calcium ion into cytosol : IMP:UniProtKB
  • response to hypoxia : IDA:BHF-UCL
  • voluntary musculoskeletal movement : IMP:MGI
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.