Neutrophil gelatinase-associated lipocalin (P11672)

Uniprot ID P11672
Protein Name Neutrophil gelatinase-associated lipocalin
Gene Name Lcn2
Species Mus musculus (Mouse)
Signal peptide(a) Y Secretome P(b) 0.887
Function Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth. .
GO - Molecular function
  • iron ion binding : IDA:UniProtKB
  • protease binding : ISO:MGI
  • protein homodimerization activity : ISO:MGI
  • small molecule binding : IEA:InterPro
GO - Biological process
  • cellular response to hydrogen peroxide : ISO:MGI
  • cellular response to interleukin-1 : IEA:Ensembl
  • cellular response to lipopolysaccharide : IEA:Ensembl
  • cellular response to nutrient levels : IEA:Ensembl
  • cellular response to tumor necrosis factor : IEA:Ensembl
  • extrinsic apoptotic signaling pathway in absence of ligand : IDA:MGI
  • innate immune response : IMP:UniProtKB
  • ion transport : IEA:UniProtKB-KW
  • iron ion homeostasis : IEA:UniProtKB-KW
  • positive regulation of cell projection organization : ISO:MGI
  • positive regulation of gene expression : ISO:MGI
  • protein homotrimerization : ISO:MGI
  • response to drug : ISO:MGI
  • response to herbicide : ISO:MGI
  • response to mycotoxin : IEA:Ensembl
  • response to virus : IDA:MGI
  • siderophore transport : IDA:UniProtKB
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.