Neural cell adhesion molecule L1 (P11627)

Uniprot ID P11627
Protein Name Neural cell adhesion molecule L1
Gene Name L1cam
Species Mus musculus (Mouse)
Signal peptide(a) Y Secretome P(b) 0.0
Function Neural cell adhesion molecule involved in the dynamics of cell adhesion and in the generation of transmembrane signals at tyrosine kinase receptors. During brain development, critical in multiple processes, including neuronal migration, axonal growth and fasciculation, and synaptogenesis. In the mature brain, plays a role in the dynamics of neuronal structure and function, including synaptic plasticity. .
GO - Molecular function
  • axon guidance receptor activity : IBA:GO_Central
  • identical protein binding : IDA:MGI
  • integrin binding : IDA:MGI
  • PDZ domain binding : ISO:MGI
  • protein domain specific binding : ISO:MGI
  • protein self-association : IPI:MGI
  • sialic acid binding : IDA:MGI
GO - Biological process
  • axon development : ISO:MGI
  • axon guidance : IDA:MGI
  • axonal fasciculation : ISO:MGI
  • cell migration : ISS:UniProtKB
  • cell surface receptor signaling pathway : IDA:MGI
  • cell-cell adhesion mediated by integrin : IMP:MGI
  • cell-matrix adhesion : ISS:UniProtKB
  • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules : IMP:MGI
  • homophilic cell adhesion via plasma membrane adhesion molecules : IMP:MGI
  • homotypic cell-cell adhesion : IMP:MGI
  • leukocyte cell-cell adhesion : IMP:MGI
  • modulation of chemical synaptic transmission : ISO:MGI
  • neuron projection development : IDA:MGI
  • positive regulation of axon extension : ISS:UniProtKB
  • positive regulation of calcium-mediated signaling : IDA:MGI
  • positive regulation of cell-cell adhesion : IMP:MGI
  • positive regulation of cell-substrate adhesion : ISO:MGI
  • regulation of ERK1 and ERK2 cascade : ISO:MGI
  • synapse organization : ISS:UniProtKB
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.