Fibroblast growth factor receptor 1 (P11362)

Uniprot ID	P11362
Protein Name	Fibroblast growth factor receptor 1
Gene Name	FGFR1
Species	Homo sapiens (Human)

Signal peptide^(a)	N	Secretome P^(b)	0.122
Function	Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation. .
GO - Molecular function	ATP binding : IEA:UniProtKB-KW fibroblast growth factor binding : IDA:UniProtKB fibroblast growth factor-activated receptor activity : IDA:UniProtKB heparin binding : IDA:UniProtKB identical protein binding : IPI:IntAct protein homodimerization activity : IPI:UniProtKB protein tyrosine kinase activity : IDA:UniProtKB receptor-receptor interaction : IDA:ParkinsonsUK-UCL SH2 domain binding : IEA:Ensembl transmembrane receptor protein tyrosine kinase activity : IBA:GO_Central
GO - Biological process	angiogenesis : IEA:Ensembl auditory receptor cell development : IEA:Ensembl branching involved in salivary gland morphogenesis : IEA:Ensembl cell maturation : IEA:Ensembl cell migration : TAS:UniProtKB chondrocyte differentiation : IEA:Ensembl chordate embryonic development : TAS:UniProtKB embryonic limb morphogenesis : IEA:Ensembl fibroblast growth factor receptor signaling pathway : IDA:UniProtKB fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development : IEA:Ensembl in utero embryonic development : IEA:Ensembl inner ear morphogenesis : IEA:Ensembl lung-associated mesenchyme development : IEA:Ensembl MAPK cascade : TAS:Reactome mesenchymal cell differentiation : IEA:Ensembl midbrain development : IEA:Ensembl middle ear morphogenesis : IEA:Ensembl multicellular organism development : IBA:GO_Central negative regulation of fibroblast growth factor production : IEA:Ensembl negative regulation of transcription by RNA polymerase II : IEA:Ensembl neuron migration : TAS:UniProtKB organ induction : IEA:Ensembl outer ear morphogenesis : IEA:Ensembl paraxial mesoderm development : IEA:Ensembl peptidyl-tyrosine phosphorylation : IDA:UniProtKB phosphatidylinositol-mediated signaling : TAS:UniProtKB positive regulation of blood vessel endothelial cell migration : IGI:BHF-UCL positive regulation of cardiac muscle cell proliferation : IEA:Ensembl positive regulation of cell differentiation : IBA:GO_Central positive regulation of cell population proliferation : IDA:UniProtKB positive regulation of endothelial cell chemotaxis to fibroblast growth factor : IDA:BHF-UCL positive regulation of kinase activity : IBA:GO_Central positive regulation of MAP kinase activity : IDA:UniProtKB positive regulation of MAPK cascade : IMP:UniProtKB positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway : IEA:Ensembl positive regulation of mesenchymal cell proliferation : IEA:Ensembl positive regulation of mitotic cell cycle DNA replication : IEA:Ensembl positive regulation of neuron differentiation : IMP:UniProtKB positive regulation of neuron projection development : IEA:Ensembl positive regulation of parathyroid hormone secretion : IEA:Ensembl positive regulation of phosphatidylinositol 3-kinase signaling : TAS:UniProtKB positive regulation of phospholipase activity : TAS:UniProtKB positive regulation of phospholipase C activity : IDA:UniProtKB positive regulation of protein kinase B signaling : TAS:Reactome positive regulation of vascular endothelial cell proliferation : IGI:BHF-UCL protein autophosphorylation : IDA:UniProtKB protein phosphorylation : NAS:UniProtKB regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling : IEA:Ensembl regulation of cell differentiation : TAS:UniProtKB regulation of extrinsic apoptotic signaling pathway in absence of ligand : IEA:Ensembl regulation of lateral mesodermal cell fate specification : IEA:Ensembl regulation of phosphate transport : IEA:Ensembl sensory perception of sound : IEA:Ensembl skeletal system development : TAS:ProtInc skeletal system morphogenesis : TAS:UniProtKB transmembrane receptor protein tyrosine kinase signaling pathway : IBA:GO_Central ureteric bud development : IEA:Ensembl ventricular zone neuroblast division : IEA:Ensembl vitamin D3 metabolic process : IEA:Ensembl

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^{(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.}
^{(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.}