Fibronectin (P11276)

Uniprot ID P11276
Protein Name Fibronectin
Gene Name Fn1
Species Mus musculus (Mouse)
Signal peptide(a) Y Secretome P(b) 0.461
Function Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts. .Anastellin binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling (By similarity). {ECO:0000250}.
GO - Molecular function
  • chaperone binding : ISO:MGI
  • disordered domain specific binding : ISO:MGI
  • enzyme binding : ISO:MGI
  • heparin binding : IEA:UniProtKB-KW
  • identical protein binding : ISO:MGI
  • integrin binding : ISO:MGI
  • mercury ion binding : ISO:MGI
  • peptidase activator activity : IDA:MGI
  • protease binding : ISO:MGI
  • protein C-terminus binding : ISO:MGI
  • signaling receptor binding : ISO:MGI
GO - Biological process
  • acute-phase response : IEA:UniProtKB-KW
  • angiogenesis : IEA:UniProtKB-KW
  • calcium-independent cell-matrix adhesion : IDA:MGI
  • cell activation : ISO:MGI
  • cell adhesion : IDA:MGI
  • cell-matrix adhesion : IDA:MGI
  • cell-substrate junction assembly : IDA:MGI
  • cellular response to interleukin-1 : ISO:MGI
  • cellular response to mercury ion : ISO:MGI
  • endodermal cell differentiation : ISO:MGI
  • extracellular matrix organization : ISO:MGI
  • glial cell migration : ISO:MGI
  • integrin activation : ISO:MGI
  • interaction with other organism via secreted substance involved in symbiotic interaction : ISO:MGI
  • interaction with symbiont : ISO:MGI
  • negative regulation of apoptotic process : ISO:MGI
  • negative regulation of transforming growth factor-beta secretion : ISO:MGI
  • peptide cross-linking : ISO:MGI
  • positive regulation of axon extension : IDA:MGI
  • positive regulation of cell migration : ISO:MGI
  • positive regulation of cell proliferation : ISO:MGI
  • positive regulation of chemotaxis : ISO:MGI
  • positive regulation of fibroblast proliferation : ISO:MGI
  • positive regulation of gene expression : ISO:MGI
  • positive regulation of substrate-dependent cell migration, cell attachment to substrate : ISO:MGI
  • regulation of cell shape : IEA:UniProtKB-KW
  • regulation of ERK1 and ERK2 cascade : ISO:MGI
  • regulation of protein phosphorylation : ISO:MGI
  • substrate adhesion-dependent cell spreading : ISO:MGI
  • wound healing : IMP:MGI
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.