| Signal peptide(a) |
N |
Secretome P(b) |
|
| Function |
Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity (By similarity). . |
| GO - Molecular function |
- enzyme binding : IPI:RGD
- peptide disulfide oxidoreductase activity : ISO:RGD
- protein disulfide oxidoreductase activity : IEA:InterPro
- thioredoxin-disulfide reductase activity : TAS:RGD
|
| GO - Biological process |
- cell redox homeostasis : ISO:RGD
- cellular response to antibiotic : IEP:RGD
- cellular response to drug : IEP:RGD
- cellular response to glucose stimulus : IEP:RGD
- cellular response to hyperoxia : IEP:RGD
- glycerol ether metabolic process : IEA:InterPro
- negative regulation of hydrogen peroxide-induced cell death : ISO:RGD
- negative regulation of protein export from nucleus : ISO:RGD
- negative regulation of transcription by RNA polymerase II : ISO:RGD
- oxidation-reduction process : ISS:UniProtKB
- positive regulation of DNA binding : ISS:UniProtKB
- positive regulation of peptidyl-serine phosphorylation : ISO:RGD
- response to activity : IEP:RGD
- response to axon injury : IEP:RGD
- response to dexamethasone : IEP:RGD
- response to drug : IEP:RGD
- response to radiation : ISS:UniProtKB
- response to selenium ion : IEP:RGD
- response to thyroxine : IEP:RGD
|