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P11214

Tissue-type plasminogen activator (P11214)

Uniprot ID P11214
Protein Name Tissue-type plasminogen activator
Gene Name Plat
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (27) Interactions
Signal peptide(a) Y Secretome P(b) 0.666
Function Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events.
GO - Molecular function
  • phosphoprotein binding : ISO:MGI
  • serine-type endopeptidase activity : IDA:MGI
  • signaling receptor binding : ISO:MGI
GO - Biological process
  • negative regulation of proteolysis : ISO:MGI
  • plasminogen activation : ISO:MGI
  • platelet-derived growth factor receptor signaling pathway : IDA:MGI
  • positive regulation of ovulation : ISO:MGI
  • proteolysis : IDA:MGI
  • response to hypoxia : IMP:MGI
  • smooth muscle cell migration : IMP:MGI
  • synaptic transmission, glutamatergic : ISO:MGI
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.