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P11152

Lipoprotein lipase (P11152)

Uniprot ID P11152
Protein Name Lipoprotein lipase
Gene Name Lpl
Species Mus musculus (Mouse)
Basic Information Experiments (2) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b) 0.781
Function The primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (VLDL). Binding to heparin sulfate proteogylcans at the cell surface is vital to the function. The apolipoprotein, APOC2, acts as a coactivator of LPL activity in the presence of lipids on the luminal surface of vascular endothelium. .
GO - Molecular function
  • apolipoprotein binding : ISO:MGI
  • heparin binding : ISS:UniProtKB
  • lipoprotein lipase activity : IDA:MGI
  • signaling receptor binding : ISO:MGI
  • triglyceride binding : ISO:MGI
  • triglyceride lipase activity : IDA:BHF-UCL
GO - Biological process
  • cholesterol homeostasis : ISO:MGI
  • fatty acid biosynthetic process : ISO:MGI
  • lipid catabolic process : ISO:MGI
  • low-density lipoprotein particle mediated signaling : ISO:MGI
  • positive regulation of chemokine secretion : ISO:MGI
  • positive regulation of cholesterol storage : ISO:MGI
  • positive regulation of macrophage derived foam cell differentiation : IGI:BHF-UCL
  • positive regulation of sequestering of triglyceride : ISO:MGI
  • response to cold : IEA:Ensembl
  • response to drug : IEA:Ensembl
  • triglyceride biosynthetic process : ISS:UniProtKB
  • triglyceride catabolic process : IDA:BHF-UCL
  • triglyceride homeostasis : ISO:MGI
  • very-low-density lipoprotein particle remodeling : ISO:MGI
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.