Collagen alpha-1(I) chain (P11087)

Uniprot ID P11087
Protein Name Collagen alpha-1(I) chain
Gene Name Col1a1
Species Mus musculus (Mouse)
Signal peptide(a) Y Secretome P(b) 0.169
Function Type I collagen is a member of group I collagen (fibrillar forming collagen).
GO - Molecular function
  • extracellular matrix structural constituent : IDA:MGI
  • identical protein binding : ISO:MGI
  • metal ion binding : IEA:UniProtKB-KW
  • platelet-derived growth factor binding : ISO:MGI
  • protease binding : ISO:MGI
GO - Biological process
  • blood vessel development : IMP:MGI
  • bone trabecula formation : IGI:MGI
  • cartilage development involved in endochondral bone morphogenesis : IMP:MGI
  • cellular response to amino acid stimulus : IDA:MGI
  • cellular response to epidermal growth factor stimulus : IEA:Ensembl
  • cellular response to fibroblast growth factor stimulus : IEA:Ensembl
  • cellular response to fluoride : IEA:Ensembl
  • cellular response to mechanical stimulus : IEP:UniProtKB
  • cellular response to retinoic acid : IEA:Ensembl
  • cellular response to transforming growth factor beta stimulus : IEA:Ensembl
  • cellular response to tumor necrosis factor : IEA:Ensembl
  • cellular response to vitamin E : IEA:Ensembl
  • collagen biosynthetic process : ISO:MGI
  • collagen fibril organization : ISO:MGI
  • collagen-activated tyrosine kinase receptor signaling pathway : ISO:MGI
  • embryonic skeletal system development : ISO:MGI
  • endochondral ossification : IMP:MGI
  • face morphogenesis : IGI:MGI
  • intramembranous ossification : IGI:MGI
  • negative regulation of cell-substrate adhesion : IDA:MGI
  • osteoblast differentiation : IEP:BHF-UCL
  • positive regulation of canonical Wnt signaling pathway : ISO:MGI
  • positive regulation of cell migration : ISO:MGI
  • positive regulation of epithelial to mesenchymal transition : ISO:MGI
  • positive regulation of transcription, DNA-templated : ISO:MGI
  • protein heterotrimerization : IDA:MGI
  • protein localization to nucleus : ISO:MGI
  • protein transport : IMP:MGI
  • response to cAMP : IEA:Ensembl
  • response to corticosteroid : IEA:Ensembl
  • response to estradiol : IEA:Ensembl
  • response to hydrogen peroxide : IEA:Ensembl
  • response to hyperoxia : IEA:Ensembl
  • response to peptide hormone : IEA:Ensembl
  • sensory perception of sound : ISO:MGI
  • skeletal system development : IMP:MGI
  • skeletal system morphogenesis : IGI:MGI
  • skin development : IMP:MGI
  • skin morphogenesis : ISO:MGI
  • tooth eruption : IEA:Ensembl
  • tooth mineralization : ISO:MGI
  • visual perception : ISO:MGI
  • wound healing : ISO:MGI
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.