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P11031

Activated RNA polymerase II transcriptional coactivator p15 (P11031)

Uniprot ID P11031
Protein Name Activated RNA polymerase II transcriptional coactivator p15
Gene Name Sub1
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.75
Function General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA).
GO - Molecular function
  • activating transcription factor binding : IEA:Ensembl
  • DNA helicase activity : IEA:Ensembl
  • double-stranded DNA binding : IEA:Ensembl
  • identical protein binding : ISO:MGI
  • single-stranded DNA binding : ISO:MGI
  • transcription coactivator activity : ISO:MGI
  • transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding : IDA:MGI
GO - Biological process
  • positive regulation of transcription initiation from RNA polymerase II promoter : IBA:GO_Central
  • protein homooligomerization : IEA:Ensembl
  • regulation of transcription by RNA polymerase II : ISO:MGI
  • SMAD protein signal transduction : IDA:MGI
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.