Prosaposin (P10960)

Uniprot ID P10960
Protein Name Prosaposin
Gene Name Psap
Species Rattus norvegicus (Rat)
Signal peptide(a) Y Secretome P(b)
Function [Prosaposin]: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling. .Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase (EC 3.2.1.45) and galactosylceramide by beta-galactosylceramidase (EC 3.2.1.46). Saposin-C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by solubilizing the substrate. {ECO:0000250|UniProtKB:P07602}.Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A (EC 3.1.6.8), GM1 gangliosides by beta-galactosidase (EC 3.2.1.23) and globotriaosylceramide by alpha-galactosidase A (EC 3.2.1.22). Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases. {ECO:0000250|UniProtKB:P07602}.Saposin-D is a specific sphingomyelin phosphodiesterase activator (EC 3.1.4.12). {ECO:0000250|UniProtKB:P07602}.Saposins are specific low-molecular mass non-enzymic proteins, they participate in the lysosomal degradation of sphingolipids, which takes place by the sequential action of specific hydrolases. {ECO:0000250|UniProtKB:P07602}.
GO - Molecular function
  • beta-galactosidase activity : ISO:RGD
  • G protein-coupled receptor binding : ISO:RGD
  • ganglioside GM1 binding : ISO:RGD
  • ganglioside GM2 binding : ISO:RGD
  • ganglioside GM3 binding : ISO:RGD
  • ganglioside GP1c binding : ISO:RGD
  • ganglioside GT1b binding : ISO:RGD
  • identical protein binding : ISO:RGD
  • phospholipid binding : ISO:RGD
  • protease binding : ISO:RGD
  • protein homodimerization activity : ISO:RGD
GO - Biological process
  • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway : ISO:RGD
  • cellular response to organic substance : ISO:RGD
  • cochlea development : ISO:RGD
  • corneocyte development : ISO:RGD
  • cornified envelope assembly : ISO:RGD
  • developmental growth : ISO:RGD
  • epithelial cell differentiation involved in prostate gland development : ISO:RGD
  • galactosylceramide catabolic process : ISO:RGD
  • ganglioside GM1 transport to membrane : ISO:RGD
  • glycolipid transport : NAS:RGD
  • lysosomal transport : ISS:UniProtKB
  • micturition : ISO:RGD
  • myelination : ISO:RGD
  • negative regulation of hydrogen peroxide-induced cell death : ISO:RGD
  • neuromuscular process controlling balance : ISO:RGD
  • positive regulation of hydrolase activity : ISO:RGD
  • positive regulation of MAPK cascade : ISO:RGD
  • prostate gland growth : ISO:RGD
  • regulation of lipid metabolic process : ISO:RGD
  • regulation of MAPK cascade : ISO:RGD
  • sensory perception of sound : ISO:RGD
  • sphingolipid metabolic process : ISO:RGD
  • walking behavior : ISO:RGD
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.